Bagci Buket, Alhatem Albert, Fidan-Ozbilgin Ozlem
Pathology and Laboratory Medicine, St. Barnabas Hospital, Livingston, USA.
Pathology, Rutgers University, Newark, USA.
Cureus. 2020 Dec 26;12(12):e12304. doi: 10.7759/cureus.12304.
The objective of this report is to present a rare case of primary cutaneous mucinous carcinoma (PCMC) manifesting with granuloma annulare (GA), and to discuss the association as a paraneoplastic phenomenon. A 65-year-old female presented with a painless, slow-growing, cystic nodule less than 1 cm over the left lateral canthus. The clinical presentation was highly suspicious of sebaceous cyst. The histopathologic examination revealed variable sizes of neoplastic cell clusters in a pool of abundant mucin. A focus of palisading lympho-histiocytic infiltrate surrounding a necrobiosis suggestive of granuloma annulare adjacent to the tumor is identified. Series of extensive investigations performed did not reveal any primary origin. GA can rarely be associated with various malignant conditions. Its association and prognostic importance to these conditions are unclear. The presence with certain malignancies and the resolution of GA with the treatment of underlying malignancy are an indicator that this condition can very well be a paraneoplastic phenomenon.
本报告的目的是呈现一例罕见的以环状肉芽肿（GA）表现的原发性皮肤黏液癌（PCMC），并讨论这种关联作为一种副肿瘤现象。一名65岁女性患者，在左内眦出现一个无痛、生长缓慢、小于1厘米的囊性结节。临床表现高度怀疑为皮脂腺囊肿。组织病理学检查显示在大量黏液池中存在大小不一的肿瘤细胞簇。在肿瘤旁发现一处栅栏状淋巴细胞 - 组织细胞浸润围绕坏死区，提示为环状肉芽肿。进行的一系列广泛检查未发现任何原发部位。GA很少与各种恶性疾病相关。其与这些疾病的关联及预后重要性尚不清楚。GA与某些恶性肿瘤同时存在，且随着潜在恶性肿瘤的治疗GA消退，这表明这种情况很可能是一种副肿瘤现象。
