Adefusika Jessica A, Pimentel Jason D, Chavan Rahul N, Brewer Jerry D
*Mayo Medical School, Mayo Clinic College of Medicine, Rochester, Minnesota; †Department of Dermatology, Mayo Clinic, Rochester, Minnesota.
Dermatol Surg. 2015 Feb;41(2):201-8. doi: 10.1097/DSS.0000000000000198.
Primary mucinous carcinoma of the skin (PMCS) is a rare adnexal eccrine sweat gland neoplasm, often mistaken for metastasis from extracutaneous sites or misdiagnosed. Primary mucinous carcinoma of the skin is a slow-growing tumor with a high recurrence rate after conventional excision.
To describe clinicopathologic features, rate of recurrence, and metastasis and to review relevant literature.
The authors identified patients with PMCS treated from January 1992 through December 2012 at Mayo Clinic. The authors retrospectively reviewed medical records and histology slides. Relevant publications were identified through Ovid MEDLINE and PubMed.
Six patients with PMCS were identified (1 male). The average age at diagnosis was 63 years. Tumor size ranged from 0.5 to 2.0 cm, and all were confined within the dermis. No evidence of metastatic mucinous adenocarcinoma was documented at the time of diagnosis. Five patients underwent Mohs micrographic surgery, and 1 was treated with wide local excision. There were no episodes of recurrence or metastases after a median follow-up of 20 months (range, 0.5-207 months).
Mohs micrographic surgery may offer reduced recurrence rates and better outcomes in PMCS. Further studies with longer follow-up and bigger cohorts of patients with PMCS are warranted.
原发性皮肤黏液癌（PMCS）是一种罕见的附属器小汗腺肿瘤，常被误诊为皮肤外部位的转移瘤或被错误诊断。原发性皮肤黏液癌是一种生长缓慢的肿瘤，传统切除后复发率高。
描述原发性皮肤黏液癌的临床病理特征、复发率和转移情况，并回顾相关文献。
作者确定了1992年1月至2012年12月在梅奥诊所接受治疗的原发性皮肤黏液癌患者。作者回顾性地查阅了病历和组织学切片。通过Ovid MEDLINE和PubMed检索相关出版物。
共确定6例原发性皮肤黏液癌患者（1例男性）。诊断时的平均年龄为63岁。肿瘤大小为0.5至2.0厘米，均局限于真皮内。诊断时未发现转移性黏液腺癌的证据。5例患者接受了莫氏显微外科手术，1例接受了广泛局部切除。中位随访20个月（范围0.5 - 207个月）后，无复发或转移事件发生。
莫氏显微外科手术可能会降低原发性皮肤黏液癌的复发率并带来更好的治疗效果。有必要对原发性皮肤黏液癌患者进行更长时间随访和更大样本量的进一步研究。
