Zeidan Bassem S, Boadu Charles, Hernandez Andrea, Frunzi Johnathan, Adetula Itioye
Internal Medicine, HCA Medical Center of Trinity, Trinity, USA.
Internal Medicine, Medical Center of Trinity, Trinity, USA.
Cureus. 2020 Dec 27;12(12):e12325. doi: 10.7759/cureus.12325.
Acute pancreatitis is an acute inflammatory process of the pancreas that is associated with multiple etiologies. The two most common causes are gallstones and acute alcohol intoxication. However, medications are often overlooked when determining the cause. Empagliflozin is a type of sodium-glucose transport protein 2 (SGLT-2) inhibitor used for the treatment of type 2 diabetes mellitus. Given that this medication is new, the adverse effects have not been fully reported in the literature. Currently, the most commonly reported side effects are genitourinary infections such as cystitis or yeast infection although acute pancreatitis as a result of empagliflozin is very rare. Here, we discuss a case of a 64-year-old female who presented with severe pancreatitis after recently initiating the use of empagliflozin. Based on the timing of her presentation and her hospital workup to rule out many of the common etiologies, it was concluded that empagliflozin was the likely cause of her acute pancreatitis. With SGLT-2 inhibitors such as empagliflozin, becoming popular as first-line in the management of diabetes, this case may hope to raise awareness of the possible adverse effects related to it. Additionally, this case also emphasizes the importance of identifying iatrogenic related pancreatitis.
急性胰腺炎是胰腺的一种急性炎症过程，与多种病因相关。最常见的两个病因是胆结石和急性酒精中毒。然而，在确定病因时，药物因素常常被忽视。恩格列净是一种用于治疗2型糖尿病的钠-葡萄糖协同转运蛋白2（SGLT-2）抑制剂。鉴于这种药物是新药，其不良反应在文献中尚未得到充分报道。目前，最常报告的副作用是泌尿生殖系统感染，如膀胱炎或酵母菌感染，尽管恩格列净导致的急性胰腺炎非常罕见。在此，我们讨论一例64岁女性病例，该患者在最近开始使用恩格列净后出现了严重胰腺炎。根据她出现症状的时间以及医院为排除许多常见病因所做的检查，得出结论认为恩格列净可能是她急性胰腺炎的病因。随着像恩格列净这样的SGLT-2抑制剂在糖尿病管理中作为一线药物变得越来越普遍，该病例可能希望提高人们对其可能的不良反应的认识。此外，该病例还强调了识别医源性相关胰腺炎的重要性。
