Kasinathan Sushma, Mohammad Ashraf Hasina, Minkowitz Sheera, Adeyinka Adebayo, Bailey-Correa Keneisha
Pediatrics, The Brooklyn Hospital Center, Brooklyn, USA.
Cureus. 2020 Dec 28;12(12):e12348. doi: 10.7759/cureus.12348.
A previously healthy 20-year-old female presented to the emergency room in April 2020 with complaints of shortness of breath, chest pain, and cough. She was diagnosed with coronavirus disease 2019 (COVID-19) infection and pulmonary embolism (PE). Workup for anemia led to the diagnosis of sickle cell disease (SCD). Patients diagnosed with COVID-19 are at an increased risk for the development of PE and venous thromboembolism (VTE). Anticoagulation prophylaxis and escalation to treatment dosing are recommended in patients admitted with moderate to severe symptoms of COVID-19. PE and VTE are relatively uncommon in the pediatric and adolescent population. Most commonly, patients are diagnosed with thrombophilia or have an underlying hypercoagulable state such as with SCD. Also, symptoms of COVID-19 infection, acute chest syndrome (ACS), and PE can have overlapping features. In this report, we present a case of a late adolescent female with SCD, who was diagnosed with COVID-19, and whose condition was complicated with PE.
一名既往健康的20岁女性于2020年4月因呼吸急促、胸痛和咳嗽前往急诊室就诊。她被诊断为2019冠状病毒病（COVID-19）感染和肺栓塞（PE）。对贫血进行检查后诊断为镰状细胞病（SCD）。诊断为COVID-19的患者发生PE和静脉血栓栓塞（VTE）的风险增加。对于因COVID-19出现中度至重度症状而入院的患者，建议进行抗凝预防并升级至治疗剂量。PE和VTE在儿童和青少年人群中相对不常见。最常见的情况是，患者被诊断为血栓形成倾向或存在潜在的高凝状态，如SCD。此外，COVID-19感染、急性胸综合征（ACS）和PE的症状可能有重叠特征。在本报告中，我们介绍了一名患有SCD的青春期晚期女性病例，她被诊断为COVID-19，病情并发PE。
