Gupta Mayank, Hoover Gary
Psychiatry, Lake Erie College of Osteopathic Medicine, Erie, USA.
Psychiatry and Behavioral Sciences, Clarion Psychiatric Center, Clarion, USA.
Cureus. 2020 Dec 29;12(12):e12360. doi: 10.7759/cureus.12360.
The key objective to demonstrate the use of Lurasidone in children or adolescents with autism spectrum disorders (ASD) and add further insights into its use in clinical practice with youth. We present four cases treated in the inpatient settings with unique challenges and their treatment course to address the unique clinical practice challenges. There is a dearth of psychopharmacologic options to treat irritability and affective symptoms in children and/or adolescents with autism spectrum disorders. Although recent research has yielded mixed results, there is still a not clear consensus on its effectiveness. Based on our experience, we found Lurasidone was an effective alternative due to its unique psychopharmacologic profile. It was well tolerated without any side effects, and its efficacy was more observed at higher doses.
证明鲁拉西酮在患有自闭症谱系障碍（ASD）的儿童或青少年中的应用，并进一步深入了解其在青少年临床实践中的应用，这是关键目标。我们介绍了在住院环境中治疗的4例具有独特挑战的病例及其治疗过程，以应对独特的临床实践挑战。在患有自闭症谱系障碍的儿童和/或青少年中，治疗易怒和情感症状的心理药理学选择匮乏。尽管最近的研究结果不一，但关于其有效性仍没有明确的共识。根据我们的经验，我们发现鲁拉西酮因其独特的心理药理学特性而成为一种有效的替代药物。它耐受性良好，没有任何副作用，并且在较高剂量下更能观察到其疗效。
