Jiang Jie, Gao Li, Lan Yongting, Wang Yang, Zhao Peiqing
Department of Clinical Laboratory, Yantai Affiliated Hospital of Binzhou Medical University, Yantai, China.
Department of Stomatology, Zibo Central Hospital, Shandong University, Zibo, China.
Front Oncol. 2021 Jan 15;10:593615. doi: 10.3389/fonc.2020.593615. eCollection 2020.
Previous studies have revealed that TIPE1 serves as a tumor suppressor gene in several tumor types. However, we demonstrated that TIPE1 can promote cervical cancer proliferation by suppressing p53 activity. Here, we showed that TIPE1 inhibits cervical cancer cell apoptosis both and . Mechanistically, we revealed that TIPE1 facilitates chemoresistance in a wild-type p53-dependent manner. The results indicated that TIPE1 is responsible for the transition from chemosensitivity to chemoresistance, and that it can serve as a promising target in cervical cancer chemotherapy.
先前的研究表明，TIPE1在几种肿瘤类型中作为肿瘤抑制基因发挥作用。然而，我们证明TIPE1可通过抑制p53活性来促进宫颈癌增殖。在此，我们表明TIPE1在[具体方面1]和[具体方面2]均抑制宫颈癌细胞凋亡。从机制上讲，我们揭示TIPE1以野生型p53依赖的方式促进化疗耐药。结果表明，TIPE1导致了从化疗敏感性到化疗耐药性的转变，并且它可作为宫颈癌化疗中有前景的靶点。
