Guo Yu-Chen, Yao Li-Yu, Tian Zhi-Sen, Shi Bing, Liu Ying, Wang Yuan-Yi
Department of Gastrointestinal Surgery, The First Hospital of Jilin University, Changchun 130021, Jilin Province, China.
Department of Pediatric Surgery, The First Hospital of Jilin University, Changchun 130021, Jilin Province, China.
World J Clin Cases. 2021 Jan 16;9(2):445-456. doi: 10.12998/wjcc.v9.i2.445.
Malignant solitary fibrous tumors (SFTs) account for 15%-20% of all SFTs, and malignant SFTs arising from the greater omentum are extremely rare. Most malignant SFTs of the greater omentum are diagnosed pathological examinations after surgery. In this study, we report a case of malignant omental SFT and review the published literature on this rare malignancy.
A 64-year-old female presented with an abdominal mass, and underwent exploratory surgery, during which a huge tumor originating from the greater omentum and intraperitoneal implants were identified and resected. The results of the pathological examination, immunohistochemistry staining, and gene sequencing led to the diagnosis of malignant SFT of the greater omentum. The patient died one and a half years later due to tumor recurrence and metastasis.
This is the first report of the application of gene sequencing in the diagnosis of malignant SFTs of the greater omentum.
恶性孤立性纤维性肿瘤（SFT）占所有SFT的15%-20%，而起源于大网膜的恶性SFT极为罕见。大多数大网膜恶性SFT是在手术后通过病理检查确诊的。在本研究中，我们报告一例大网膜恶性SFT病例，并回顾已发表的关于这种罕见恶性肿瘤的文献。
一名64岁女性因腹部肿块就诊，接受了 exploratory surgery，术中发现并切除了一个起源于大网膜的巨大肿瘤及腹腔内种植灶。病理检查、免疫组化染色和基因测序结果确诊为大网膜恶性SFT。患者在一年半后因肿瘤复发和转移死亡。
这是基因测序应用于大网膜恶性SFT诊断的首例报告。
