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Tackling immunosenescence to improve COVID-19 outcomes and vaccine response in older adults.
Lancet Healthy Longev. 2020 Nov;1(2):e55-e57. doi: 10.1016/S2666-7568(20)30011-8. Epub 2020 Nov 9.
2
Signs of immunosenescence correlate with poor outcome of mRNA COVID-19 vaccination in older adults.
Nat Aging. 2022 Oct;2(10):896-905. doi: 10.1038/s43587-022-00292-y. Epub 2022 Oct 14.
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Vaccine-induced protection in aging adults and pandemic response.
Biochem Biophys Res Commun. 2021 Jan 29;538:218-220. doi: 10.1016/j.bbrc.2020.10.090. Epub 2020 Nov 17.
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Shelter from the cytokine storm: pitfalls and prospects in the development of SARS-CoV-2 vaccines for an elderly population.
Semin Immunopathol. 2020 Oct;42(5):619-634. doi: 10.1007/s00281-020-00821-0. Epub 2020 Nov 6.
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Immunosenescence and Severe Acute Respiratory Syndrome Coronavirus 2 Vaccine Development.
J Infect Dis. 2020 Nov 13;222(12):2114. doi: 10.1093/infdis/jiaa564.
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Impaired Functional T-Cell Response to SARS-CoV-2 After Two Doses of BNT162b2 mRNA Vaccine in Older People.
Front Immunol. 2021 Nov 16;12:778679. doi: 10.3389/fimmu.2021.778679. eCollection 2021.
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Age-related changes in the immune system and challenges for the development of age-specific vaccines.
Ann Med. 2025 Dec;57(1):2477300. doi: 10.1080/07853890.2025.2477300. Epub 2025 Mar 20.
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Antibody responses to COVID-19 vaccines in older adults.
J Med Virol. 2022 Apr;94(4):1650-1654. doi: 10.1002/jmv.27531. Epub 2021 Dec 27.
10
Immunosenescence and COVID-19.
Mech Ageing Dev. 2022 Jun;204:111672. doi: 10.1016/j.mad.2022.111672. Epub 2022 Apr 1.

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Progress of immune senescence in multiple myeloma treatment resistance.
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Delayed Mucosal Antiviral Responses Despite Robust Peripheral Inflammation in Fatal COVID-19.
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The immunoreactive signature of monocyte-derived dendritic cells from patients with Down syndrome.
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Loss of Pla2r1 decreases cellular senescence and age-related alterations caused by aging and Western diets.
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The central role of DNA damage in immunosenescence.
Front Aging. 2023 Jul 3;4:1202152. doi: 10.3389/fragi.2023.1202152. eCollection 2023.

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In-Hospital Use of Statins Is Associated with a Reduced Risk of Mortality among Individuals with COVID-19.
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The quest to slow ageing through drug discovery.
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Simvastatin Improves Neutrophil Function and Clinical Outcomes in Pneumonia. A Pilot Randomized Controlled Clinical Trial.
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Senolytics in idiopathic pulmonary fibrosis: Results from a first-in-human, open-label, pilot study.
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mTORC Inhibitors as Broad-Spectrum Therapeutics for Age-Related Diseases.
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TORC1 inhibition enhances immune function and reduces infections in the elderly.
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Find drugs that delay many diseases of old age.
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The effect of ageing of the immune system on vaccination responses.
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