Margenthaler Julie A, Dietz Jill R, Chatterjee Abhishek
Department of Surgery, Washington University School of Medicine, St. Louis, MO, USA.
Department of Surgery, Case Western Reserve School of Medicine, Cleveland, OH, USA.
Ann Surg Oncol. 2021 Apr;28(4):2120-2127. doi: 10.1245/s10434-020-09534-y. Epub 2021 Jan 31.
Significant progress has been made in the treatment and outcome of breast cancer. Some of the most dramatic strides have been in the surgical management of breast cancer. Breast-conserving therapy (BCT), including wide local excision of the tumor followed by irradiation, has become a standard treatment option for women with early-stage invasive breast cancer. Large cooperative group trials have contributed to the paradigm shift from mastectomy to BCT. This review reports the landmark BCT trials that provided the data for current surgical practices. The review also describes the body of literature contributing to the increasing use of oncoplastic techniques for patients undergoing BCT.
乳腺癌的治疗及预后已取得显著进展。其中一些最显著的进展体现在乳腺癌的外科治疗方面。保乳治疗（BCT），包括肿瘤的广泛局部切除及随后的放疗，已成为早期浸润性乳腺癌女性的标准治疗选择。大型合作组试验推动了从乳房切除术到保乳治疗的模式转变。本综述报告了为当前外科手术实践提供数据的具有里程碑意义的保乳治疗试验。该综述还描述了有助于接受保乳治疗的患者更多地使用肿瘤整形技术的文献主体。
