Department of Analytical Chemistry, Burjassot, University of Valencia, Valencia, Spain.
Compr Rev Food Sci Food Saf. 2021 Mar;20(2):1681-1716. doi: 10.1111/1541-4337.12702. Epub 2021 Jan 31.
Antibiotics are widely used to prevent or treat some diseases in human and veterinary medicine and also as animal growth promoters. The presence of these compounds in foods derived from food-producing animals can be a risk for human health. Consequently, regulatory agencies have set maximum residue limits for antibiotics in food samples. Therefore, the development of novel methodologies for its determination in food samples is required. Specifically, the analysis and quantification of these substances in meat tissues is a challenge for the analytical chemistry research community. This is due to the complexity of the matrix and the low detection limits required by the regulatory agencies. In this sense, a comprehensive review on the development of new sample preparation treatments involving extraction, cleanup, and enrichment steps of antibiotics in meat samples in combination with sensitive and sophisticated determination techniques that have been carry out in the last years is necessary. Therefore, the aim of this work is to summarize the published methodologies for the determination of antibiotics from 2016 until the beginning of the second semester of 2020. The first part of this review includes an introduction about antibiotic families, followed by sample preparation and determination techniques applied to the different families. Finally, a detailed discussion of the current trends and the future possible perspectives in this field are also included.
抗生素被广泛用于预防或治疗人类和兽医医学中的某些疾病，也被用作动物生长促进剂。这些化合物在来自动物食品的食物中的存在可能对人类健康构成风险。因此，监管机构已经为食品样品中的抗生素设定了最大残留限量。因此，需要开发用于检测食品样品中抗生素的新方法。具体而言，分析和定量肉组织中的这些物质是分析化学研究界面临的挑战。这是由于基质的复杂性和监管机构所需的低检测限所致。在这方面，有必要对过去几年中在肉类样品中涉及抗生素提取，净化和富集步骤的新型样品制备处理方法的开发进行全面综述，以及与这些方法结合的灵敏而复杂的测定技术。因此，本工作的目的是总结 2016 年至 2020 年上半年发表的抗生素测定方法。本综述的第一部分包括有关抗生素家族的介绍，随后是应用于不同家族的样品制备和测定技术。最后，还详细讨论了该领域的当前趋势和未来可能的前景。
