胰十二指肠切除术后残余胰腺体积与内分泌功能的关系

Relationship Between Remnant Pancreatic Volume and Endocrine Function After Pancreaticoduodenectomy.

作者信息

Yamazaki Tatsuya, Aoki Takeshi, Tashiro Yoshihiko, Koizumi Tomotake, Kusano Tomokazu, Matsuda Kazuhiro, Fujimori Akira, Yamada Kosuke, Nogaki Koji, Hakozaki Tomoki, Wada Yusuke, Shibata Hideki, Tomioka Kodai, Enami Yuta, Murakami Masahiko

机构信息

Department of General and Gastroenterological Surgery, School of Medicine, 13059Showa University, Tokyo, Japan.

出版信息

Am Surg. 2022 Feb;88(2):233-237. doi: 10.1177/0003134821989049. Epub 2021 Jan 30.

DOI:10.1177/0003134821989049

PMID:33522272

Abstract

BACKGROUND

Decreased pancreatic volume (PV) is a predictive factor for diabetes mellitus (DM) after surgery. There are few reports on PV and endocrine function pre- and post-surgery. We investigated the correlation between PV and insulin secretion.

METHODS

Seventeen patients underwent pancreaticoduodenectomy (PD) Pre- and post-surgery PV and C-peptide index (CPI) measurements were performed. Additionally, the correlation between PV and CPI was analyzed.

RESULTS

The mean preoperative PV (PPV) was 55.1 ± 31.6 mL, postoperative remnant PV (RPV) was 25.3±17.3 mL, and PV reduction was 53%. The mean preoperative C-peptide immunoreactivity (CPR) was 1.39 ± .51 and postoperative CPR was .85±.51. The mean preoperative CPI was 1.29±.72 and postoperative CPI was .73 ± .48. Significant correlations were observed between RPV and post CPR (ρ = .507, P = .03) and post CPI (ρ = .619, P = .008).

DISCUSSION

There was a significant correlation between RPV and CPI after PD. A smaller RPV resulted in lower insulin secretion ability, increasing the potential risk of new-onset DM after PD.

摘要

背景

胰腺体积（PV）减小是术后糖尿病（DM）的一个预测因素。关于手术前后PV与内分泌功能的报道较少。我们研究了PV与胰岛素分泌之间的相关性。

方法

17例患者接受了胰十二指肠切除术（PD）。进行手术前后PV和C肽指数（CPI）测量。此外，分析PV与CPI之间的相关性。

结果

术前平均PV（PPV）为55.1±31.6 mL，术后残余PV（RPV）为25.3±17.3 mL，PV减少53%。术前平均C肽免疫反应性（CPR）为1.39±0.51，术后CPR为0.85±0.51。术前平均CPI为1.29±0.72，术后CPI为0.73±0.48。观察到RPV与术后CPR（ρ = 0.507，P = 0.03）和术后CPI（ρ = 0.619，P = 0.008）之间存在显著相关性。