Department of Clinical Pharmacy, Faculty of Pharmacy, Jordan University of Science and Technology (JUST), Irbid, Jordan.
Al-Balqa Applied University, Amman, Jordan.
J Matern Fetal Neonatal Med. 2022 Dec;35(25):4841-4846. doi: 10.1080/14767058.2020.1869719. Epub 2021 Jan 31.
Organophosphorus (OP) pesticides are widely used worldwide. The effect of OP exposure during pregnancy on the offspring is inconsistent in the current literature. Moreover, similar studies in the Middle East are lacking.
To examine the effects of OP exposure in utero on the outcome of pregnancies in an agricultural region in Jordan.
A prospective study, employing a questionnaire to collect women demographic data. Hospital records were collected for newborns' birth data. In addition, urine samples during the third trimester were collected from pregnant women and then analyzed for six OP metabolites to measure exposure.
One of the metabolites, DEDTP, was negatively correlated with gestational age and Apgar scores 1 and 5. There were no other significant associations.
Exposure to OP during pregnancy is not highly associated with any negative anthropometric characteristics of the newborns; it is probably offset by other factors.
有机磷（OP）农药在世界范围内广泛使用。目前文献中关于妊娠期间接触 OP 对后代的影响并不一致。此外，中东地区类似的研究也很少。
在约旦的一个农业地区，研究宫内接触有机磷对妊娠结局的影响。
采用问卷调查收集孕妇的人口统计学数据，前瞻性研究。医院记录收集新生儿的出生数据。此外，在妊娠晚期收集孕妇的尿液样本，然后分析六种 OP 代谢物以测量接触情况。
其中一种代谢物 DEDTP 与胎龄和新生儿第 1 分钟和第 5 分钟的阿普加评分呈负相关。没有其他显著关联。
妊娠期间接触 OP 与新生儿的任何负面人体测量特征没有高度相关性；可能被其他因素抵消。
