Department of Community Medicine, Faculty of Medicine, Chiang Mai University, 110 Inthavaroros, Sri Phum Subdistrict, Muang District, Chiang Mai, 50200, Thailand.
Department of Pediatrics, Faculty of Medicine, Chiang Mai University, 110 Inthavaroros, Sri Phum Subdistrict, Muang District, Chiang Mai, 50200, Thailand.
Environ Sci Pollut Res Int. 2021 Sep;28(33):45064-45074. doi: 10.1007/s11356-021-13974-8. Epub 2021 Apr 15.
Organophosphate (OP) pesticides may accumulate in pregnant agricultural workers, resulting in adverse effects on the growth and development of the fetus and neonates. This study aims to evaluate a possible association between prenatal urinary OP metabolite levels among pregnant agricultural workers and birth outcomes of infants. This study also investigated the factors associated with urinary OP metabolites among pregnant agricultural workers. The spot urine samples were collected and analyzed for six OP metabolite levels. Birth outcomes data were abstracted from medical records. Multiple regression analysis found that gestational age at childbirth was negatively associated with diethylphosphate (DEP) levels (β = -0.073; 95% CI, -0.121, -0.024). Apgar score at 1 and 5 min after birth were negatively associated with diethyldithiophosphate (DEDTP) levels (β = -0.036; 95% CI, -0.069, -0.003; and β = -0.034, 95% CI, -0.057, -0.011, respectively). In addition, DEDTP levels were negatively associated with maternal age (β = -0.181; 95% CI, -0.339, -0.023), and dimethylphosphate (DMP) levels were positively associated with frequency of agricultural work during pregnancy (β = 31.554; 95% CI, 0.194, 62.914). Our results indicate that prenatal OP exposure can cause adverse birth outcomes in babies. Therefore, it is necessary to develop an effective strategy for reducing prenatal exposure to OP pesticides.
有机磷 (OP) 农药可能会在孕妇农业工人体内蓄积，对胎儿和新生儿的生长发育产生不良影响。本研究旨在评估孕妇农业工人产前尿中 OP 代谢物水平与婴儿出生结局之间可能存在的关联，并探讨与孕妇尿中 OP 代谢物相关的因素。采集并分析了这些孕妇的尿样，以检测六种 OP 代谢物水平。从病历中提取出生结局数据。多变量回归分析发现，分娩时的胎龄与二乙基磷酸酯 (DEP) 水平呈负相关 (β = -0.073; 95% CI, -0.121, -0.024)。出生后 1 分钟和 5 分钟的 Apgar 评分与二乙基二硫代磷酸酯 (DEDTP) 水平呈负相关 (β = -0.036; 95% CI, -0.069, -0.003;β = -0.034, 95% CI, -0.057, -0.011)。此外，DEDTP 水平与产妇年龄呈负相关 (β = -0.181; 95% CI, -0.339, -0.023)，DMP 水平与孕期农业工作频率呈正相关 (β = 31.554; 95% CI, 0.194, 62.914)。我们的研究结果表明，产前 OP 暴露可能导致婴儿出生结局不良。因此，有必要制定有效的策略来减少产前 OP 农药的暴露。
