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年龄只是一个数字:在透析血管通路规划中是否忽视了虚弱问题?

Age is just a number: Is frailty being ignored in vascular access planning for dialysis?

机构信息

Department of Research and Development, University Hospitals Birmingham, Edgbaston, Birmingham, UK.

Department of Nephrology and Transplantation, University Hospitals Birmingham, Edgbaston, Birmingham, UK.

出版信息

J Vasc Access. 2022 Mar;23(2):192-197. doi: 10.1177/1129729821989902. Epub 2021 Jan 30.

Abstract

Current international guidelines advocate fistula creation as first choice for vascular access in haemodialysis patients, however, there have been suggestions that in certain groups of patients, in particular the elderly, a more tailored approach is needed. The prevalence of more senior individuals receiving renal replacement therapy has increased in recent years and therefore including patient age in decision making regarding choice of vascular access for dialysis has gained more relevance. However, it seems that age is being used as a surrogate for overall clinical condition and it can be proposed that frailty may be a better basis to considering when advising and counselling patients with regard to vascular access for dialysis. Frailty is a clinical condition in which the person is in a vulnerable state with reduced functional capacity and has a higher risk of adverse health outcomes when exposed to stress inducing events. Prevalence of frailty increases with age and has been associated with an increased risk of mortality, hospitalisation, disability and falls. Chronic kidney disease is associated with premature ageing and therefore patients with kidney disease are prone to be frailer irrespective of age and the risk increases further with declining kidney function. Limited data exists on the relationship between frailty and vascular access, but it appears that frailty may have an association with poorer outcomes from vascular access. However, further research is warranted. Due to complexity in decision making in dialysis access, frailty assessment could be a key element in providing patient-centred approach in planning and maintaining vascular access for dialysis.

摘要

目前的国际指南主张在血液透析患者中首先创建瘘管作为血管通路的选择,然而,有人认为,在某些患者群体中,特别是老年人,需要采取更有针对性的方法。近年来,接受肾脏替代治疗的老年人比例有所增加,因此,在决定透析血管通路选择时,将患者年龄纳入考虑因素变得更加重要。然而,似乎年龄被用作整体临床状况的替代指标,因此可以提出,衰弱可能是在为透析血管通路提供咨询和建议时考虑的更好基础。衰弱是一种临床状况,患者处于脆弱状态,功能能力下降,在面临应激诱导事件时,健康不良结局的风险更高。衰弱的患病率随着年龄的增长而增加,并且与死亡率、住院率、残疾和跌倒的风险增加相关。慢性肾脏病与过早衰老有关,因此,无论年龄大小,患有肾脏病的患者更容易衰弱,而随着肾功能的下降,风险进一步增加。关于衰弱与血管通路之间的关系,数据有限,但衰弱似乎与血管通路的不良结局有关。然而,还需要进一步的研究。由于透析通路的决策复杂,衰弱评估可能是在规划和维持透析血管通路时提供以患者为中心方法的关键因素。

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