Department of Life, Health and Environmental Sciences, University of L'Aquila, L'Aquila, Italy.
Hum Vaccin Immunother. 2021 Jul 3;17(7):2268-2272. doi: 10.1080/21645515.2020.1852869. Epub 2021 Jan 31.
In Italy, vaccination against hepatitis B became compulsory for all the newborns and 12-years-old adolescents in 1991. The main purpose of this study was to evaluate the persistence of long-term protection against HBV in medical students of the University of L'Aquila and in postgraduates Medical Doctors (HCWs) working in San Salvatore Hospital. The second aim was to study the variables associated with a protective anti-HBs antibody level, such as age at vaccination, gender, time elapsed from the last dose of vaccination.Three hundred and forty-two subjects were enrolled from January 2017 to January 2019 and a blood sample was collected to evaluate the levels of serum HBsAg, anti-HBs and anti-HBc. Statistical analysis calculated a multivariable logistic regression model to examine predictors of a protective anti-HBs titer. The larger part (239, 70%) of the students had an anti-HBs titer >10 mIU/mL, those were statistically significant older (26.7 vs 24.5 years, < .001), vaccinated at age 12 years (83.5% vs 59.9% among vaccinate at infancy, < .001) and more frequently attending postgraduate medical school (80.8% vs 57.5% among healthcare profession school, < .001). The multivariable logistic regression model showed that HBV vaccination at age of 12 was significantly and independently associated with protective titers (OR = 10.27, = .019).The results agreed with literature on HBV vaccination, confirming the efficacy of vaccination after 20 years. In particular, our results suggest that adolescent administration is the main predictor of a protective title, regardless of gender, course and years since vaccinations.
在意大利，1991 年开始为所有新生儿和 12 岁的青少年接种乙肝疫苗。本研究的主要目的是评估拉奎拉大学医学生和圣萨尔瓦托雷医院工作的医学研究生（HCWs）体内乙型肝炎病毒（HBV）长期保护的持久性。第二个目的是研究与保护性抗-HBs 抗体水平相关的变量，如接种年龄、性别、最后一次接种疫苗后时间的流逝。2017 年 1 月至 2019 年 1 月期间，共招募了 342 名受试者，并采集血样评估血清 HBsAg、抗-HBs 和抗-HBc 水平。统计分析计算了多变量逻辑回归模型，以检查保护性抗-HBs 滴度的预测因子。较大部分（239，70%）的学生抗-HBs 滴度>10 mIU/mL，他们的年龄统计学上显著较大（26.7 岁比 24.5 岁，<0.001），12 岁时接种疫苗（83.5%比婴儿期接种疫苗者的 59.9%，<0.001），更经常参加研究生医学课程（80.8%比卫生保健专业学校的 57.5%，<0.001）。多变量逻辑回归模型显示，12 岁时接种 HBV 疫苗与保护性滴度显著相关（OR=10.27，=0.019）。研究结果与乙肝疫苗接种文献一致，证实了接种 20 年后疫苗的有效性。特别是，我们的结果表明，青少年接种是保护性标题的主要预测因子，与性别、课程和接种疫苗后的年份无关。
