Department of Maternal, Child and Adolescent Health, School of Public Health, Anhui Medical University, Hefei, Anhui 230032, China.
MOE Key Laboratory of Population Health Across Life Cycle, Hefei, Anhui 230032, China.
Soc Cogn Affect Neurosci. 2021 May 4;16(5):484-491. doi: 10.1093/scan/nsab016.
This study aimed to investigate the brain grey matter volume (GMV) related to problematic mobile phone use (PMPU), and whether these regions of GMV play a potential moderating role in the relationship between PMPU and depressive symptoms. We recruited 266 students who underwent magnetic resonance imaging (MRI) scanning. PMPU and depressive symptoms were assessed by a self-rating questionnaire for adolescent PMPU and patient health questionnaire-9, respectively. A multiple regression model was performed to detect GMV and white matter (WM) integrity associated with PMPU by voxel-based morphometry (VBM) and tract-based spatial statistics (TBSS) methods, and the moderating analysis was conducted by PROCESS using SPSS software. VBM analysis found an inverse correlation between the GMV of the anterior cingulate gyrus (ACC) and right fusiform gyrus (FFG) with PMPU (PFDR < 0.05), and TBSS analysis revealed that fractional anisotropy (FA) in the body of the corpus callosum was negatively correlated with PMPU. The correlation between PMPU and depressive symptoms was moderated by the GMV of the ACC. These results suggest that the GMV of the ACC and right FFG, as well as FA in the body of the corpus callosum, was related to PMPU, and we further found that increased GMV of the ACC could reduce the relationship between PMPU and depressive symptoms in college students.
本研究旨在探讨与手机过度使用（PMPU）相关的大脑灰质体积（GMV），以及这些 GMV 区域是否在 PMPU 与抑郁症状之间的关系中发挥潜在的调节作用。我们招募了 266 名接受磁共振成像（MRI）扫描的学生。通过青少年 PMPU 自评问卷和患者健康问卷-9 分别评估 PMPU 和抑郁症状。通过基于体素的形态学（VBM）和基于束的空间统计学（TBSS）方法，使用多元回归模型检测与 PMPU 相关的 GMV 和白质（WM）完整性，使用 SPSS 软件中的 PROCESS 进行调节分析。VBM 分析发现，前扣带皮层（ACC）和右侧梭状回（FFG）的 GMV 与 PMPU 呈负相关（PFDR<0.05），TBSS 分析显示胼胝体体部的各向异性分数（FA）与 PMPU 呈负相关。PMPU 与抑郁症状之间的相关性受到 ACC 的 GMV 的调节。这些结果表明，ACC 和右侧 FFG 的 GMV 以及胼胝体体部的 FA 与 PMPU 有关，我们进一步发现，ACC 的 GMV 增加可以减轻大学生中 PMPU 与抑郁症状之间的关系。
