PLCG2 rs72824905 变异可降低阿尔茨海默病和多发性硬化症的风险。

PLCG2 rs72824905 Variant Reduces the Risk of Alzheimer's Disease and Multiple Sclerosis.

机构信息

Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China.

Department of Pathology, The Affiliated Hospital of Weifang Medical University, Weifang, China.

出版信息

J Alzheimers Dis. 2021;80(1):71-77. doi: 10.3233/JAD-201140.

DOI:10.3233/JAD-201140

PMID:33523007

Abstract

We aimed to evaluate the association of PLCG2 rs72824905 variant with Alzheimer's disease (AD) and multiple sclerosis (MS) using large-scale genetic association study datasets. We selected 50,024 AD cases and 467,330 controls, and 32,367 MS cases and 36,012 controls. We found moderate heterogeneity of rs72824905 in different studies. We found significant association between rs72824905 G allele and reduced AD risk (OR = 0.66, 95% CI 0.59-0.74, p = 5.91E-14). Importantly, rs72824905 G allele could also significantly reduce the risk of MS with OR = 0.94, p = 3.63E-05. Hence, the effects of rs72824905 on AD and MS are consistent.

摘要

我们旨在使用大规模遗传关联研究数据集评估 PLCG2 rs72824905 变体与阿尔茨海默病 (AD) 和多发性硬化症 (MS) 的关联。我们选择了 50024 例 AD 病例和 467330 例对照，以及 32367 例 MS 病例和 36012 例对照。我们发现 rs72824905 在不同研究中的异质性中等。我们发现 rs72824905 G 等位基因与降低 AD 风险显著相关（OR=0.66，95%CI 0.59-0.74，p=5.91E-14）。重要的是，rs72824905 G 等位基因也可以显著降低 MS 的风险，OR=0.94，p=3.63E-05。因此，rs72824905 对 AD 和 MS 的影响是一致的。