Department of Ophthalmology, Hanyang University Hospital, Hanyang University College of Medicine, Seoul, Republic of Korea.
Department of Pediatrics, Hanyang University Hospital, Hanyang University College of Medicine, Seoul, Republic of Korea.
Invest Ophthalmol Vis Sci. 2021 Feb 1;62(2):2. doi: 10.1167/iovs.62.2.2.
To investigate brain white matter pathways using magnetic resonance diffusion tensor imaging (DTI) and correlate the findings with developmental outcomes at 18 months of corrected age in preterm infants with and without retinopathy of prematurity (ROP).
In this prospective cohort study, probabilistic maps of the 26 white matter pathways associated with motor, cognitive, visual, and limbic/language functions were generated in 84 preterm infants using DTI obtained at term-equivalent age. The mean fractional anisotropy (FA) and mean diffusivity (MD) values were compared between those with and without ROP. Developmental outcomes were assessed using the third edition of Bayley Scales of Infant and Toddler Development (BSID-III) at 18 months of corrected age. Multiple regression analyses were performed to confirm the association among developmental outcomes, white matter pathways, and ROP or severe ROP after adjusting for potential confounders.
The white matter pathways were insignificantly associated with ROP or severe ROP. There were no significant differences in the FA and MD values of the pathways between ROP infants treated with and without bevacizumab therapy. Furthermore, there were no significant differences in BSID-III scores between infants with and without ROP or severe ROP. The BSID-III scores at 18 months of age showed a significant association with FA or MD values in several pathways.
ROP or severe ROP was insignificantly associated with maturation delay of the white matter pathways. Developmental outcomes were similar between preterm infants with and without ROP or severe ROP or between ROP infants with and without intravitreal bevacizumab therapy.
使用磁共振弥散张量成像（DTI）研究脑白质通路，并将结果与伴有和不伴有早产儿视网膜病变（ROP）的早产儿在矫正 18 月龄时的发育结果相关联。
在这项前瞻性队列研究中，通过在足月龄时获得的 DTI，在 84 名早产儿中生成了与运动、认知、视觉和边缘/语言功能相关的 26 条白质通路的概率图。比较了 ROP 患儿和非 ROP 患儿之间的平均各向异性分数（FA）和平均弥散度（MD）值。使用贝利婴幼儿发育量表第三版（BSID-III）在矫正 18 月龄时评估发育结果。进行多元回归分析，以确认在调整了潜在混杂因素后，发育结果、白质通路与 ROP 或重度 ROP 之间的关联。
白质通路与 ROP 或重度 ROP 无显著相关性。接受贝伐单抗治疗与未接受贝伐单抗治疗的 ROP 患儿的通路 FA 和 MD 值无显著差异。此外，ROP 患儿和无 ROP 或重度 ROP 患儿之间的 BSID-III 评分无显著差异。18 月龄时的 BSID-III 评分与几个通路的 FA 或 MD 值呈显著相关。
ROP 或重度 ROP 与白质通路成熟延迟无显著相关性。伴有和不伴有 ROP 或重度 ROP 的早产儿以及接受和未接受玻璃体内贝伐单抗治疗的 ROP 患儿之间的发育结果相似。
