Pediatric Pharmacology and Pharmacometrics, University Children's Hospital Basel UKBB, Spitalstrasse 33, 4056, Basel, Switzerland.
Department of Neonatology, University Children's Hospital Basel UKBB, Basel, Switzerland.
J Pharmacokinet Pharmacodyn. 2021 Jun;48(3):401-410. doi: 10.1007/s10928-020-09735-8. Epub 2021 Feb 1.
The objectives are to characterize oscillations of physiological functions such as heart rate and body temperature, as well as the sleep cycle from behavioral states in generally stable preterm neonates during the first 5 days of life. Heart rate, body temperature as well as behavioral states were collected during a daily 3-h observation interval in 65 preterm neonates within the first 5 days of life. Participants were born before 32 weeks of gestational age or had a birth weight below 1500 g; neonates with asphyxia, proven sepsis or malformation were excluded. In total 263 observation intervals were available. Heart rate and body temperature were analyzed with mathematical models in the context of non-linear mixed effects modeling, and the sleep cycles were characterized with signal processing methods. The average period length of an oscillation in this preterm neonate population was 159 min for heart rate, 290 min for body temperature, and the average sleep cycle duration was 19 min. Oscillation of physiological functions as well as sleep cycles can be characterized in very preterm neonates within the first few days of life. The observed parameters heart rate, body temperature and sleep are running in a seemingly uncorrelated pace at that stage of development. Knowledge about such oscillations may help to guide nursing and medical care in these neonates as they do not yet follow a circadian rhythm.
目的是描述生理功能（如心率和体温）的波动，以及在生命的头 5 天内，通常稳定的早产儿的行为状态的睡眠周期。在生命的头 5 天内，在 65 名早产儿的每日 3 小时观察间隔内收集了心率、体温和行为状态。参与者出生于妊娠 32 周之前或出生体重低于 1500 克；排除有窒息、确诊败血症或畸形的新生儿。共有 263 个观察间隔可用。使用非线性混合效应建模的数学模型分析心率和体温，并使用信号处理方法描述睡眠周期。在这个早产儿群体中，心率的平均波动周期长度为 159 分钟，体温的平均波动周期长度为 290 分钟，平均睡眠周期持续时间为 19 分钟。在生命的头几天，非常早产儿的生理功能波动和睡眠周期可以被描述。在那个发育阶段，观察到的参数（心率、体温和睡眠）似乎没有关联。了解这些波动可能有助于指导这些新生儿的护理和医疗，因为他们还没有遵循昼夜节律。
