从一名被诊断患有非典型自闭症谱系障碍的21岁男性患者身上建立诱导多能干细胞（iPS）系（SDUKIi006-A）。
Establishment of an induced pluripotent stem (iPS) cell line (SDUKIi006-A) from a 21-year old male patient diagnosed with atypical autism disorder.
作者信息
Kamand Morad, Forsberg Sheena Louise, Thomassen Mads, Ilieva Mirolyuba, Meyer Morten, Svenningsen Åsa Fex, Michel Tanja Maria
机构信息
Department of Clinical Research, Department of Psychiatry, University of Southern Denmark, Odense, Denmark; Department of Neurobiology Research, Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark; Psychiatry in the Region of Southern Denmark, Odense University Hospital, Denmark.
Department of Clinical Research, Department of Psychiatry, University of Southern Denmark, Odense, Denmark; Psychiatry in the Region of Southern Denmark, Odense University Hospital, Denmark.
出版信息
Stem Cell Res. 2021 Mar;51:102185. doi: 10.1016/j.scr.2021.102185. Epub 2021 Jan 18.
Autism is a complex neuropsychiatric disorder defined by significant challenges in communication skills and social behavior as well as repetitive conduct and interests. Recent advances in stem cell technologies allow in vitro modeling of the underlying molecular disease mechanisms. Using integration-free episomal plasmids, we have generated a novel iPS cell line (SDUKIi006-A) from a patient diagnosed with atypical autism ("FYNEN cohort" of Southern Denmark). Characterization of the established cell line validated its expression of pluripotency markers, differentiation into the three germ layers, and the absence of chromosomal abnormalities.
自闭症是一种复杂的神经精神疾病，其特征为沟通技巧、社交行为以及重复行为和兴趣方面存在重大障碍。干细胞技术的最新进展使得能够在体外模拟潜在的分子疾病机制。我们使用无整合附加体质粒，从一名被诊断患有非典型自闭症的患者（丹麦南部的“FYNEN队列”）中生成了一种新型诱导多能干细胞系（SDUKIi006-A）。对建立的细胞系进行的表征验证了其多能性标志物的表达、向三个胚层的分化以及染色体异常的不存在。
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