Radiology Department, Northwick Park Hospital, London North West University Healthcare NHS Trust, Watford Road, London, HA1 3UJ, United Kingdom.
Radiology Department, Northwick Park Hospital, London North West University Healthcare NHS Trust, Watford Road, London, HA1 3UJ, United Kingdom.
Eur J Radiol. 2021 Mar;136:109560. doi: 10.1016/j.ejrad.2021.109560. Epub 2021 Jan 27.
Immunoglobulin G4-related disease (IgG4-RD) is a newly defined fibro-inflammatory multisystemic condition defined by a triad of diagnostic criteria based on clinical presentation, biochemical and histopathological findings. Whereas some subsites of this disease have been well described in the literature so far (e.g. pancreas, kidneys, retroperitoneum, salivary glands), more recently identified anatomical sites of involvement in the head and neck are less well understood (e.g. nose, paranasal sinuses).
This pictorial review details the imaging appearances of extracranial IgG4-RD in the Head & Neck. Multimodality imaging appearance and features are presented, with reference to the published literature to date.
Following a subsite-based approach, we present both the most common and the more rarely encountered imaging patterns of IgG4-RD in the extracranial head and neck, along with the relevant differential diagnoses to consider. Our institutional experience not only cements what is already known in the existing literature on this topic, but also reveals new imaging features of IgG4-RD, notably in the sinonasal tract.
This pictorial review of extracranial head & neck IgG4-RD will enable radiologists to recognise the features of this condition and propose it as a differential diagnosis to include alongside other probable entities. It establishes the place of the radiologist in the diagnosis and management of IgG4-RD.
免疫球蛋白 G4 相关疾病（IgG4-RD）是一种新定义的纤维炎症性多系统疾病，其诊断标准基于临床表现、生化和组织病理学发现，包括三联征。虽然迄今为止，该疾病的一些部位在文献中已有很好的描述（例如胰腺、肾脏、腹膜后、唾液腺），但最近发现的头颈部受累解剖部位了解较少（例如鼻、鼻旁窦）。
本图像综述详细介绍了头颈部外的 IgG4-RD 的影像学表现。我们展示了多模态成像表现和特征，并参考了迄今为止的文献。
根据部位的方法，我们展示了头颈部外 IgG4-RD 最常见和较不常见的影像学表现，并考虑了相关的鉴别诊断。我们的机构经验不仅证实了该主题现有文献中已知的内容，还揭示了 IgG4-RD 的新的影像学特征，特别是在鼻旁窦。
本对外的头颈部 IgG4-RD 的图像综述将使放射科医生能够识别出这种疾病的特征，并将其作为鉴别诊断纳入可能的其他疾病。它确立了放射科医生在 IgG4-RD 的诊断和管理中的地位。
