全身性癫痫发作期间脑代谢的三重核磁共振研究。
Triple nuclear NMR studies of cerebral metabolism during generalized seizure.
作者信息
Schnall M D, Yoshizaki K, Chance B, Leigh J S
机构信息
University of Pennsylvania, Department of Biochemistry and Biophysics, Philadelphia 19104.
出版信息
Magn Reson Med. 1988 Jan;6(1):15-23. doi: 10.1002/mrm.1910060103.
PMID:3352502
Abstract
Noninvasive NMR spectroscopy of 1H, 31P, and 23Na is performed simultaneously to study brain metabolism during grand mal seizures. Decreases in PCr and increases in lactate associated with seizure as well as an intracellular shift of the Na+ ion pool are demonstrated. A close correlation between the phosphate potential and the intensity of the seizure, as well as the intra/extracellular ionic gradient, is shown.
摘要
同时进行¹H、³¹P和²³Na的无创核磁共振波谱分析，以研究癫痫大发作期间的脑代谢。结果显示，癫痫发作时磷酸肌酸减少、乳酸增加，以及Na⁺离子池的细胞内转移。研究还表明，磷酸势能与癫痫发作强度以及细胞内/外离子梯度之间存在密切相关性。
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