Institute of Pharmaceutical Science, King's College London, London SE1 9NH, UK.
Int J Mol Sci. 2021 Jan 28;22(3):1278. doi: 10.3390/ijms22031278.
Evidence is reviewed for the role of glutathione in providing a ligand for the cytosolic iron pool. The possibility of histidine and carnosine forming ternary complexes with iron(II)glutathione is discussed and the physiological significance of these interactions considered. The role of carnosine in muscle, brain, and kidney physiology is far from established and evidence is presented that the iron(II)-binding capability of carnosine relates to this role.
本文回顾了谷胱甘肽在提供细胞质铁池配体方面的作用。讨论了组氨酸和肉碱与铁（II）谷胱甘肽形成三元配合物的可能性，并考虑了这些相互作用的生理意义。肉碱在肌肉、大脑和肾脏生理学中的作用远未确定，并提出证据表明肉碱的铁（II）结合能力与这一作用有关。
