Department of Ophthalmology, University Medical Center, Johannes Gutenberg University Mainz, Langenbeckstr. 1, 55131 Mainz, Germany.
Int J Mol Sci. 2021 Jan 28;22(3):1296. doi: 10.3390/ijms22031296.
Age-related macular degeneration (AMD) is a common irreversible ocular disease characterized by vision impairment among older people. Many risk factors are related to AMD and interact with each other in its pathogenesis. Notably, oxidative stress and choroidal vascular dysfunction were suggested to be critically involved in AMD pathogenesis. In this review, we give an overview on the factors contributing to the pathophysiology of this multifactorial disease and discuss the role of reactive oxygen species and vascular function in more detail. Moreover, we give an overview on therapeutic strategies for patients suffering from AMD.
年龄相关性黄斑变性（AMD）是一种常见的不可逆眼部疾病，其特征是老年人视力受损。许多风险因素与 AMD 相关，并且在其发病机制中相互作用。值得注意的是，氧化应激和脉络膜血管功能障碍被认为与 AMD 的发病机制密切相关。在这篇综述中，我们概述了导致这种多因素疾病病理生理学的因素，并详细讨论了活性氧和血管功能的作用。此外，我们还概述了 AMD 患者的治疗策略。
