Taylor Peter W
School of Pharmacy, University College London, London WC1N 1AX, U.K.
Emerg Top Life Sci. 2017 Apr 21;1(1):85-92. doi: 10.1042/ETLS20160017.
The relentless increase in antibiotic resistance among all major groups of bacterial pathogens shows no sign of abating. The situation is exacerbated by a marked decline in the number of new antibiotics entering the marketplace. It is essential that new ways to treat severe bacterial infections are investigated before the antibiotic well runs dry. This review covers many promising approaches, some novel and some based on old ideas that were not considered viable when clinicians were able to exploit a wide palette of cheap and effective antibacterial chemotherapeutics. These approaches include the use of photosensitive dyes, bacteriophage and phage-encoded proteins, and agents that compromise virulence and antibiotic-resistance machineries. I also make a case for continuing in some form with tried and trusted platforms for drug discovery that served society well in the past.
所有主要类别的细菌病原体的抗生素耐药性持续上升，且毫无减弱的迹象。新进入市场的抗生素数量显著下降，使情况更加恶化。在抗生素储备枯竭之前，研究治疗严重细菌感染的新方法至关重要。本综述涵盖了许多有前景的方法，有些是新颖的，有些则基于旧理念，而这些旧理念在临床医生能够使用多种廉价且有效的抗菌化疗药物时被认为不可行。这些方法包括使用光敏染料、噬菌体和噬菌体编码蛋白，以及破坏毒力和抗生素耐药机制的药物。我还主张以某种形式继续采用过去曾很好地服务于社会的经过试验和验证的药物研发平台。
