The Second School of Clinical Medicine, 70570Southern Medical University, Guangzhou, Guangdong, People's Republic of China.
89346Guangdong Provincial People's Hospital affiliated with South China University of Technology, Guangzhou, Guangdong, People's Republic of China.
Angiology. 2021 Aug;72(7):616-624. doi: 10.1177/0003319721989185. Epub 2021 Feb 2.
Contrast-associated acute kidney injury (CA-AKI) is a major adverse complication of intravascular administration of contrast medium. Current studies have shown that hypoalbuminemia might be a novel risk factor of CA-AKI. This systematic review and meta-analysis was performed to evaluate the predictive value of hypoalbuminemia for CA-AKI. Relevant studies were identified in Ovid-Medline, PubMed, Embase, and Cochrane Library up to December 31, 2019. Two authors independently screened studies, consulting with a third author when necessary to resolve discrepancies. The pooled odds ratio (OR) was calculated to assess the association between hypoalbuminemia and CA-AKI using a random-effects model or fixed-effects model. Eight relevant studies involving a total of 18 687 patients met our inclusion criteria. The presence of hypoalbuminemia was associated with an increased risk of CA-AKI development (pooled OR: 2.59, 95% CI: 1.80-3.73). Hypoalbuminemia is independently associated with the occurrence of CA-AKI and may be a potentially modifiable factor for clinical intervention. This systematic review and meta-analysis was registered in PROSPERO (CRD42020168104).
对比剂相关急性肾损伤（CA-AKI）是血管内应用对比剂的主要不良并发症。目前的研究表明，低白蛋白血症可能是 CA-AKI 的一个新的危险因素。本系统评价和荟萃分析旨在评估低白蛋白血症对 CA-AKI 的预测价值。截至 2019 年 12 月 31 日，在 Ovid-Medline、PubMed、Embase 和 Cochrane Library 中检索到相关研究。两名作者独立筛选研究，必要时与第三名作者协商解决分歧。使用随机效应模型或固定效应模型计算汇总优势比（OR），以评估低白蛋白血症与 CA-AKI 之间的关联。共有 8 项符合纳入标准的相关研究，共纳入 18687 例患者。低白蛋白血症的存在与 CA-AKI 发展的风险增加相关（汇总 OR：2.59，95%CI：1.80-3.73）。低白蛋白血症与 CA-AKI 的发生独立相关，可能是临床干预的一个潜在可改变因素。本系统评价和荟萃分析已在 PROSPERO（CRD42020168104）中注册。
