Division of Haematology, Department of Medicine, University of Cape Town and Groote Schuur Hospital, Cape Town, South Africa.
Division of Haematological Pathology, University of Cape Town and National Health Laboratory Service, Groote Schuur Hospital, Cape Town, South Africa.
Clin Lymphoma Myeloma Leuk. 2021 Apr;21(4):e348-e352. doi: 10.1016/j.clml.2020.12.006. Epub 2020 Dec 11.
The characteristics and outcomes of patients with acute promyelocytic leukemia (APL) from sub-Saharan Africa have not been published.
We report retrospectively on consecutively diagnosed APL patients treated in Cape Town, South Africa, during 1998-2019. A total of 69 patients were treated, of whom 27 (39%) were classified as having high risk APL.
Early death rates at 7 and 30 days were 7% and 13%, respectively, including 4 patients who died before any treatment could be administered. Overall survival at 3 years was 76.5% (95% confidence interval, 63.9-85.2) for the entire cohort, and 82.5% (95% confidence interval, 69.7-90.2) if patients who died within 7 days of diagnosis were excluded. For 13 patients (18.8%), there was a delay of 5 or more days from time of initial presentation at a peripheral hospital until arrival at the leukemia center and administration of all-trans retinoic acid; only 1 of these patients died within 30 days.
Despite the challenges faced in the public healthcare system of a developing country, outcomes of APL patients treated at our center are similar to outcomes from developed countries.
来自撒哈拉以南非洲的急性早幼粒细胞白血病（APL）患者的特征和结局尚未发表。
我们回顾性报告了 1998 年至 2019 年期间在南非开普敦连续诊断的 APL 患者。共有 69 例患者接受了治疗，其中 27 例（39%）被归类为高危 APL。
7 天和 30 天的早期死亡率分别为 7%和 13%，包括 4 例在给予任何治疗之前死亡的患者。整个队列的 3 年总生存率为 76.5%（95%置信区间，63.9-85.2），如果排除诊断后 7 天内死亡的患者，则为 82.5%（95%置信区间，69.7-90.2）。对于 13 名患者（18.8%），从最初在周边医院就诊到白血病中心就诊并给予全反式维甲酸的时间延迟了 5 天或更长时间；这些患者中只有 1 人在 30 天内死亡。
尽管在发展中国家的公共医疗体系中面临挑战，但我们中心治疗的 APL 患者的结局与发达国家相似。
