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鉴定大鼠松果体中 circRNAs 及其相关 ceRNA 网络的日常变化。

Identifying daily changes in circRNAs and circRNA-associated-ceRNA networks in the rat pineal gland.

机构信息

Department of Laboratory Animals, Jilin Provincial Key Laboratory of Animal Model, Jilin University, Changchun 130062, Jilin, P.R. China.

出版信息

Int J Med Sci. 2021 Jan 14;18(5):1225-1239. doi: 10.7150/ijms.51743. eCollection 2021.

DOI:10.7150/ijms.51743
PMID:33526984
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7847611/
Abstract

Circular RNAs (circRNAs) are a new class of covalently closed circular RNA molecules that are involved in many biological processes. However, information about circRNAs in the pineal gland, particularly that of rats, is limited. To establish resources for the study of the rat pineal gland, we performed transcriptome analysis of the pineal glands during the day and night. In this study, 1413 circRNAs and 1989 miRNAs were identified in the pineal gland of rats during the night and day using the Illumina platform. Forty differentially expressed circRNAs and 93 differentially expressed miRNAs were obtained, among which 20 circRNAs and 37 miRNAs were significantly upregulated during the day and 20 circRNAs and 56 miRNAs were significantly upregulated during the night. As circRNAs have been reported to work as miRNA sponges, we predicted 15940 interactions among 40 circRNAs, 93 miRNAs and 400 mRNAs with differential diurnal expression using miRanda and TargetScan to build a ceRNA regulatory network in the rat pineal gland. The diurnal expression profile of circRNAs in the rat pineal gland may provide additional information about the role of circRNAs in regulating changes in melatonin circadian rhythms. The analyzed data reported in this study will be an important resource for future studies to elucidate the altered physiology of circRNAs in diurnal rhythms.

摘要

环状 RNA（circRNAs）是一类新的共价闭合环状 RNA 分子，参与许多生物学过程。然而，松果体中环状 RNA 的信息，特别是大鼠的信息有限。为了建立研究大鼠松果体的资源，我们对白天和黑夜的松果体进行了转录组分析。在这项研究中，我们使用 Illumina 平台在大鼠的夜间和白天的松果体中鉴定出 1413 个 circRNAs 和 1989 个 miRNAs。获得了 40 个差异表达的 circRNAs 和 93 个差异表达的 miRNAs，其中 20 个 circRNAs 和 37 个 miRNAs 在白天显著上调，20 个 circRNAs 和 56 个 miRNAs 在夜间显著上调。由于 circRNAs 已被报道作为 miRNA 的海绵，我们使用 miRanda 和 TargetScan 预测了 40 个 circRNAs、93 个 miRNAs 和 400 个具有昼夜差异表达的 mRNAs 之间的 15940 个相互作用，构建了大鼠松果体中的 ceRNA 调控网络。大鼠松果体中 circRNAs 的昼夜表达谱可能为 circRNAs 调节褪黑素昼夜节律变化的作用提供了额外的信息。本研究中分析的数据将是未来阐明昼夜节律中 circRNAs 改变的生理学的重要资源。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c30/7847611/8953859a7966/ijmsv18p1225g007.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c30/7847611/e09a60df0264/ijmsv18p1225g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c30/7847611/6dfbf91b333c/ijmsv18p1225g005.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c30/7847611/8953859a7966/ijmsv18p1225g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c30/7847611/9e60460a9819/ijmsv18p1225g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c30/7847611/ee18395008ed/ijmsv18p1225g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c30/7847611/ab5f7d31ac4e/ijmsv18p1225g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c30/7847611/e09a60df0264/ijmsv18p1225g004.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c30/7847611/4ab286781419/ijmsv18p1225g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c30/7847611/8953859a7966/ijmsv18p1225g007.jpg

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