Department of Cardiology, St Bartholomew's Hospital, London, UK.
Baker Heart and Diabetes Research Institute, Melbourne, Australia.
J Cardiovasc Electrophysiol. 2021 Apr;32(4):941-948. doi: 10.1111/jce.14923. Epub 2021 Feb 10.
Catheter ablation is an established effective approach for the treatment of atrial fibrillation (AF) in patients with heart failure, however, the role of cryoablation in this setting is unclear. Procedural success and left ventricular systolic dysfunction (LVEF) improvement in patients with LVEF ≤ 45% undergoing index catheter ablation with cryoablation were evaluated. Freedom from AF recurrence was seen in 43% rising to 59% following repeat procedure. There were significant improvements in LVEF and functional status at long-term follow-up. Results were comparable to a contemporaneous cohort of heart failure patients undergoing index ablation with radiofrequency ablation. Cryoablation is an effective first-line AF ablation approach in the setting of heart failure.
导管消融是心力衰竭合并心房颤动（房颤）患者的一种有效治疗方法，然而，冷冻消融在此类患者中的作用尚不明确。本研究旨在评估冷冻消融用于左心室射血分数（LVEF）≤45%的患者行导管消融时的即刻手术成功率和左心室收缩功能（LVEF）改善情况。结果显示，首次消融后 43%的患者无房颤复发，重复消融后这一比例升至 59%。长期随访时，LVEF 和功能状态显著改善。研究结果与同期接受射频消融的心力衰竭患者的队列研究结果相当。在心力衰竭患者中，冷冻消融是一种有效的一线房颤消融方法。
