Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
Department of Medical Virology, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Rev Med Virol. 2021 Nov;31(6):e2219. doi: 10.1002/rmv.2219. Epub 2021 Feb 2.
Men who have sex with men (MSM) are at increased risk of human papillomavirus (HPV) infection because of their high-risk sexual behaviours. In this study, a meta-analytic approach was used to systematically analyse the literature to elucidate the prevalence and genotype distribution of anal, penile, oral and urethral HPV infection among MSM in the world. To carry out this systematic review, five electronic databases including Web of Science, PubMed, Scopus, Embase, and Google Scholar were searched for relevant studies published from January 2012 to November 2019, and pertinent data were collected from the eligible articles. The pooled HPV prevalence was calculated for each anatomical region using a random-effect model weighted by the inverse variance method. The meta-analysis was performed using the "Metaprop" function in the R package Meta. The overall pooled prevalence of anal, penile, oral and urethral HPV infection among MSM were 78.4% (95% confidence interval [CI]: 75.6%-81.0%), 36.2% (95% CI: 29.1%-44.0%), 17.3% (95% CI: 13.6%-21.7%) and 15.4% (95% CI: 7.8%-27.9%), respectively. Stratified analyses showed that the prevalences of HPV were significantly higher in HIV-positive than HIV-negative MSM. The most frequent HPV high-risk type detected in the anus, penis and oral cavity was HPV-16 (19.9%, 4.9% and 3.1%, respectively). HPV infection is rising in MSM because of high-risk sexual behaviours, suggesting an increased future risk of developing HPV-related diseases and malignancies in this population.
男男性行为者（MSM）由于其高危性行为，感染人乳头瘤病毒（HPV）的风险增加。在这项研究中，采用荟萃分析方法系统地分析文献，阐明了全球 MSM 肛门、阴茎、口腔和尿道 HPV 感染的流行率和基因型分布。为了进行这项系统评价，检索了五个电子数据库，包括 Web of Science、PubMed、Scopus、Embase 和 Google Scholar，以查找 2012 年 1 月至 2019 年 11 月发表的相关研究，并从合格文章中收集相关数据。使用Inverse variance method 加权的随机效应模型计算每个解剖区域的 HPV 总流行率。使用 R 包 Meta 中的“Metaprop”函数进行荟萃分析。MSM 肛门、阴茎、口腔和尿道 HPV 感染的总体合并流行率分别为 78.4%（95%置信区间 [CI]：75.6%-81.0%）、36.2%（95% CI：29.1%-44.0%）、17.3%（95% CI：13.6%-21.7%）和 15.4%（95% CI：7.8%-27.9%）。分层分析表明，HIV 阳性 MSM 中的 HPV 流行率明显高于 HIV 阴性 MSM。在肛门、阴茎和口腔中检测到的最常见的 HPV 高危型是 HPV-16（分别为 19.9%、4.9%和 3.1%）。由于高危性行为，MSM 中的 HPV 感染呈上升趋势，这表明该人群中 HPV 相关疾病和恶性肿瘤的未来风险增加。
