van Rongen E, Kuijpers W C, van der Kogel A J
Radiobiological Institute TNO, Rijswijk, The Netherlands.
NCI Monogr. 1988(6):19-22.
Cisplatin was administered as a single iv dose of 5 mg/kg in WAG/Rij female rats at intervals of 7 days or 30 minutes before or 7 days after graded irradiation of the left kidney. The unirradiated right kidney was removed 4 weeks after the x-ray treatment. Kidney function was determined by measuring urine osmolality and plasma urea. The kidney function parameters did not change measurably in animals treated with cisplatin alone. Only differences in urine osmolality were observed between the groups that received combined treatment or irradiation only. Long-term renal fibrosis was assessed by measuring the hydroxyproline content. Significant increases in renal hydroxyproline content were observed in animals receiving treatment with cisplatin either 7 days before or 7 days after irradiation, compared with animals receiving irradiation alone.
顺铂以5毫克/千克的单次静脉注射剂量给予WAG/Rij雌性大鼠，在左侧肾脏分级照射前7天或30分钟，或照射后7天，间隔为7天。在X射线治疗4周后，将未照射的右肾切除。通过测量尿渗透压和血浆尿素来测定肾功能。单独用顺铂治疗的动物的肾功能参数没有明显变化。仅在接受联合治疗或仅接受照射的组之间观察到尿渗透压的差异。通过测量羟脯氨酸含量来评估长期肾纤维化。与仅接受照射的动物相比，在照射前7天或照射后7天接受顺铂治疗的动物的肾脏羟脯氨酸含量显著增加。
