Moulder J E, Fish B L
Department of Radiation Oncology, Medical College of Wisconsin, Milwaukee 53226.
NCI Monogr. 1988(6):35-9.
We are using a rat model to study the effects of sequencing on the combined toxicity of renal irradiation and cisplatin (cis-Pt). Unanesthetized female WAG/RijMCW rats were given bilateral kidney irradiation (20 Gy in 9 fractions), preceded or followed by single ip doses of cis-Pt. Renal irradiation causes an increase in the acute toxicity of cis-Pt given 3-9 months after irradiation. Low-dose cis-Pt given immediately before irradiation, or as long as 9 months after irradiation, causes a decrease in the latent period for radiation nephritis and an increase in its severity. When given 3.7 to 7.7 months prior to irradiation, cis-Pt has a less severe effect on radiation nephritis. The greatest enhancement of radiation nephritis is seen for cis-Pt given 3 months after irradiation. Additive effects of cis-Pt and radiation on renal function can explain much, but not all, of the combined toxicity.
我们正在使用大鼠模型来研究顺铂（cis-Pt）给药顺序对肾脏照射和顺铂联合毒性的影响。未麻醉的雌性WAG/RijMCW大鼠接受双侧肾脏照射（9次分割，共20 Gy），在照射前或照射后单次腹腔注射顺铂。肾脏照射会导致照射后3至9个月给予的顺铂急性毒性增加。在照射前即刻或照射后长达9个月给予低剂量顺铂，会使放射性肾炎的潜伏期缩短，病情加重。在照射前3.7至7.7个月给予顺铂，对放射性肾炎的影响较小。照射后3个月给予顺铂时，放射性肾炎的增强作用最为明显。顺铂和辐射对肾功能的叠加效应可以解释大部分但不是全部的联合毒性。
