Department of Chemical Engineering, Istanbul Technical University, Istanbul, Turkey.
J Biomed Mater Res B Appl Biomater. 2021 Oct;109(10):1478-1487. doi: 10.1002/jbm.b.34807. Epub 2021 Feb 2.
Poly(ω-pentadecalactone-co-ε-caprolactone) copolymer (PDL-CL) is an enzymatically synthesized aliphatic biopolyester, which has been participated in a nanofibrous structure for the first time. Electrospinning of this synthetic polymer by blending with a natural polymer such as gelatin (Gel) could provide new characteristics that are significant for biomedical applications, such as drug delivery, wound healing, and tissue engineering. In the present study, PDL-CL/Gel nanofibrous membranes were successfully produced and characterized. The average diameter of nanofibers was 305.0 ± 45.5 nm that may be beneficial in applications mentioned above. In order to increase hydrolytic resistance, cross-linking with glutaraldehyde vapor was applied. Cross-linking for 2 h was enough to obtain a nanofibrous membrane that was able to resist in pH 7.4 phosphate buffered saline for 30 days. In addition, contact angle measurement results had shown that, cross-linked nanofibrous membrane had good wettability, which is a required specification to be applied in biomedical field. Hence, this study provides an overview on fabrication of fine PDL-CL/Gel nanofibers, which may have potential to be used in biomedical area.
聚（ω-十五内酯-共-ε-己内酯）共聚物（PDL-CL）是一种酶合成的脂肪族生物聚酯，它首次被用于纳米纤维结构中。通过与明胶（Gel）等天然聚合物共混来进行电纺丝，可以为药物输送、伤口愈合和组织工程等生物医学应用提供新的特性。在本研究中，成功制备并表征了 PDL-CL/Gel 纳米纤维膜。纳米纤维的平均直径为 305.0±45.5nm，这可能对上述应用有益。为了提高水解稳定性，采用戊二醛蒸气进行交联。交联 2h 足以获得能够在 pH7.4 磷酸盐缓冲盐溶液中耐受 30 天的纳米纤维膜。此外，接触角测量结果表明，交联纳米纤维膜具有良好的润湿性，这是在生物医学领域应用所需的规格。因此，本研究概述了精细的 PDL-CL/Gel 纳米纤维的制备，它们可能有潜力应用于生物医学领域。
