TCG Life sciences Pvt. Ltd, BN-7, Sector V, Salt Lake City, Kolkata 700091, India.
Department of Chemistry, University of North Bengal, Darjeeling 734013, India.
Org Biomol Chem. 2021 Feb 25;19(7):1604-1609. doi: 10.1039/d0ob02510k.
We demonstrate herein the first example of a palladium(ii) catalyzed regioselective ortho-C(sp2)-H arylation in aqueous medium (a sustainable solvent) utilizing 8-AIP (8-aminoimidazo[1,2-a]pyridine) as a promising and removable bidentate directing group/auxilliary. This newly developed protocol features a broad substrate scope with excellent functional group tolerance and enables an expeditious route to a library of unsymmetrical amides in good to excellent yields with exclusive site-selectivity.
本文首次展示了钯（ii）催化的在水相介质（一种可持续的溶剂）中区域选择性的邻位 C(sp2)-H 芳基化反应的实例，利用 8-AIP（8-氨基咪唑并[1,2-a]吡啶）作为一种有前途的、可去除的双齿导向基团/辅助基团。该新开发的方法具有广泛的底物范围，对功能基团具有优异的耐受性，并能够快速构建一系列非对称酰胺，产率良好至优秀，具有独特的位点选择性。
