以8-氨基咪唑并[1,2-]吡啶（8-AIP）为导向基团的铜（II）催化的位点选择性C(sp)-H胺化反应。

Copper(II)-catalyzed, site-selective C(sp)-H amination using 8-aminoimidazo[1,2-]pyridine (8-AIP) as a directing group.

作者信息

Hajra Arun Kumar, Ghosh Prasanjit, Roy Chandrayee, Kundu Mrinalkanti, Ghosh Shibaji, Das Sajal

机构信息

TCG Life Sciences Pvt. Ltd, BN-7, Salt Lake City, Kolkata-700091, India.

Department of Chemistry, University of North Bengal, Darjeeling-734013, India.

出版信息

Org Biomol Chem. 2024 Aug 14;22(32):6617-6630. doi: 10.1039/d4ob01008f.

DOI:10.1039/d4ob01008f

PMID:39101878

Abstract

An efficient copper(II)-catalyzed regioselective C(sp)-H amination of arenes/heteroarenes has been developed with the assistance of 8-AIP (8-aminoimidazo[1,2-]pyridine) as an efficacious 6,5-fused bicyclic removable chelating auxiliary. This operationally simple approach is scalable, has a broad substrate scope, and is highly compatible with functional groups. Furthermore, post-diversification of the synthesized derivatives demonstrates the methodology's synthetic adaptability.

摘要

在8-氨基咪唑并[1,2 -]吡啶（8-AIP）作为一种有效的6,5-稠合双环可去除螯合助剂的辅助下，已开发出一种高效的铜（II）催化的芳烃/杂芳烃区域选择性C(sp)-H胺化反应。这种操作简单的方法具有可扩展性，底物范围广泛，并且与官能团具有高度兼容性。此外，合成衍生物的后期多样化证明了该方法的合成适应性。