First Department of Dermatology-Venereology, Aristotle University, State Hospital of Skin and Venereal Diseases, Thessaloniki, Greece.
Int J Dermatol. 2021 Jun;60(6):730-735. doi: 10.1111/ijd.15378. Epub 2021 Feb 2.
Though androgenetic alopecia (AGA) is one of the most common diseases affecting both sexes and all races, its pathogenesis is not completely clarified. The aim of this study was to investigate the role of the four major prostaglandins (PGs) (PGE , PGD , PGF , and PI or prostacyclin) in the pathogenesis of AGA in males and females.
Human scalp biopsies were obtained from 30 adults (17 males and 13 females) suffering from AGA and from 30 healthy adults (18 males and 12 females). In each subject, two skin biopsies were performed, one from the frontal bald area and another one from the occipital area with normal hair growth. In the healthy group, biopsies were taken from both areas too. In each sample, all four PGs were measured.
In the patient group, PGD and prostacyclin or PGI levels were increased in bald compared to haired scalp. On the contrary, measurements of PGE and PGF showed that they were diminished in bald areas compared to haired areas. PG levels in healthy samples were comparable to the haired areas.
These results support that there is a fine balance between these four proteins in scalp hair follicles, and its maintenance may be crucial for hair growth. Furthermore, their receptors could be potential targets for treatment of AGA.
尽管雄激素性脱发（AGA）是一种影响男女和所有种族的最常见疾病之一，但它的发病机制尚未完全阐明。本研究旨在探讨四大前列腺素（PGs）（PGE 、PGD 、PGF 和 PI 或前列环素）在男性和女性 AGA 发病机制中的作用。
从 30 名患有 AGA 的成年人（男性 17 名，女性 13 名）和 30 名健康成年人（男性 18 名，女性 12 名）中获得头皮活检。在每个受试者中，进行了两次皮肤活检，一次来自额部光秃区，另一次来自有正常头发生长的枕部。在健康组中，两个部位均进行了活检。在每个样本中，均测量了所有四种 PG。
在患者组中，与有发区相比，PGD 和前列环素或 PGI 水平在光秃区升高。相反，PGE 和 PGF 的测量值表明，与有发区相比，光秃区的含量减少。健康样本中的 PG 水平与有发区相当。
这些结果支持头皮毛囊中这四种蛋白之间存在精细平衡，其维持可能对毛发生长至关重要。此外，它们的受体可能是 AGA 治疗的潜在靶点。
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