Department of Green Chemistry and Technology Synthesis, Bioresources and Bioorganic Chemistry Research Group, Ghent University, Coupure Links 653, 9000, Ghent, Belgium.
Department of Chemistry and Centre for Sustainable Chemistry, Ghent University, Krijgslaan 281,S-3, 9000, Ghent, Belgium.
Chemistry. 2021 Mar 26;27(18):5653-5657. doi: 10.1002/chem.202100190. Epub 2021 Mar 3.
The use of weak bases and mild conditions is currently the most sustainable and attractive synthetic approach for the preparation of late-transition metal complexes, some of which are widely used in catalysis, medicinal chemistry and materials science. Herein, the use of cuprate, aurate or palladate species for a continuous flow preparation of Cu , Au and Pd -NHC complexes is reported. All reactions examined proceed under extremely mild conditions and make use of technical grade acetone as solvent. The scalability of the process was exemplified in a multigram-scale synthesis of [Cu(IPr)Cl].
目前，使用弱碱和温和条件来制备晚期过渡金属配合物是最具可持续性和吸引力的合成方法，其中一些配合物广泛应用于催化、药物化学和材料科学。在此，我们报告了使用铜酸盐、金酸盐或钯酸盐物种在连续流条件下制备 Cu、Au 和 Pd-NHC 配合物的方法。所有考察的反应都在极其温和的条件下进行，并使用工业级丙酮作为溶剂。该方法的可扩展性在 [Cu(IPr)Cl]的多克级合成中得到了例证。
