Tidsskr Nor Laegeforen. 2020 Dec 29;140(2). doi: 10.4045/tidsskr.20.0956. Print 2021 Feb 2.
Cardiovascular disease and cancer have been described as possible risk factors for COVID-19 mortality. The purpose of this study was to investigate whether a history of cardiovascular disease or cancer affects the risk of dying after a COVID-19 diagnosis in Norway.
Data were compiled from the Norwegian Surveillance System for Communicable Diseases, the Norwegian Cardiovascular Disease Registry and the Cancer Registry of Norway. Univariable and multivariable regression models were used to calculate both relative and absolute risk.
In the first half of 2020, 8 809 people tested positive for SARS-CoV-2 and 260 COVID-19-associated deaths were registered. Increasing age, male sex (relative risk (RR): 1.5; confidence interval (CI): 1.2-2.0), prior stroke (RR: 1.5; CI: 1.0-2.1) and cancer with distant metastasis at the time of diagnosis (RR: 3.0; CI: 1.1-8.2) were independent risk factors for death after a diagnosis of COVID-19. After adjusting for age and sex, myocardial infarction, atrial fibrillation, heart failure, hypertension, and non-metastatic cancer were no longer statistically significant risk factors for death.
The leading risk factor for death among individuals who tested positive for SARS-CoV-2 was age. Male sex, and a previous diagnosis of stroke or cancer with distant metastasis were also associated with an increased risk of death after a COVID-19 diagnosis.
心血管疾病和癌症已被描述为 COVID-19 死亡的可能危险因素。本研究旨在调查在挪威，心血管疾病或癌症史是否会影响 COVID-19 诊断后的死亡风险。
数据来自挪威传染病监测系统、挪威心血管疾病登记处和挪威癌症登记处。使用单变量和多变量回归模型计算相对风险和绝对风险。
2020 年上半年，8809 人 SARS-CoV-2 检测呈阳性，登记了 260 例 COVID-19 相关死亡。年龄增长、男性（相对风险（RR）：1.5；置信区间（CI）：1.2-2.0）、既往卒中（RR：1.5；CI：1.0-2.1）和诊断时存在远处转移的癌症（RR：3.0；CI：1.1-8.2）是 COVID-19 诊断后死亡的独立危险因素。在调整年龄和性别后，心肌梗死、心房颤动、心力衰竭、高血压和非转移性癌症不再是死亡的统计学显著危险因素。
在 SARS-CoV-2 检测呈阳性的个体中，死亡的主要危险因素是年龄。男性、既往卒中或诊断时存在远处转移的癌症也与 COVID-19 诊断后死亡风险增加相关。
