Ma Rui, He Jie, Xu Biao, Zhao Rugang, Zhang Qiang
Department of Orthopedics, Beijing Ditan Hospital, Capital Medical University, Beijing, China.
J Int Med Res. 2021 Feb;49(2):300060520980639. doi: 10.1177/0300060520980639.
Although low bone mineral density (BMD) is associated with an increased risk of fracture, few studies have assessed fracture rates in patients with human immunodeficiency virus (HIV).
The occurrence of subclinical fractures in patients with HIV was assessed. Pearson's chi-square test was used to analyze the relationship between subclinical fractures and related factors.
Fifty patients with HIV were included, among whom 11 were diagnosed with subclinical fractures. These 11 patients had a mean body mass index of 24.127 ± 3.482 kg/m, smoked a mean of 142.091 ± 3.482 cigarettes/month, drank a mean of 61.545 ± 13.026 mL/day of alcohol, had a mean CD4 T cell count of 247.727 ± 181.679 cells/mm, had a mean duration of acquired immunodeficiency syndrome (AIDS) of 4.27 ± 0.786 years, and had a mean BMD of the third lumbar spine of 0.810 ± 0.063 g/cm. The AIDS duration and BMD of the third lumbar spine were significantly associated with subclinical fractures. The BMD of the third lumbar spine was negatively correlated with subclinical fractures.
A significant negative correlation was found between the BMD of the third lumbar spine and subclinical fractures.
尽管低骨矿物质密度（BMD）与骨折风险增加相关，但很少有研究评估人类免疫缺陷病毒（HIV）患者的骨折发生率。
评估HIV患者亚临床骨折的发生情况。采用Pearson卡方检验分析亚临床骨折与相关因素之间的关系。
纳入50例HIV患者，其中11例被诊断为亚临床骨折。这11例患者的平均体重指数为24.127±3.482kg/m，平均每月吸烟142.091±3.482支，平均每日饮酒61.545±13.026mL，平均CD4 T细胞计数为247.727±181.679个/mm，获得性免疫缺陷综合征（AIDS）平均病程为4.27±0.786年，第三腰椎平均骨密度为0.810±0.063g/cm。AIDS病程和第三腰椎骨密度与亚临床骨折显著相关。第三腰椎骨密度与亚临床骨折呈负相关。
第三腰椎骨密度与亚临床骨折之间存在显著负相关。
