Ghosh J, Das S
Chittaranjan National Cancer Research Center, Calcutta, India.
Neoplasma. 1988;35(1):41-9.
The effect of vitamin A deficiency and supplementation on the incidence of tumors, tumor growth and life expectancy was assessed in a murine model. Although the nature of response varied with respect to the tumor types studied, in general an increase in incidence of tumor take and further growth was noted with a concomitant fall in the survival rates in the group maintained on a vitamin A deficient diet. Supplemental vitamin A produced a prolongation of the latent period and delayed appearance of the tumor, reduced incidence and growth and improved life expectancy. Such effects seem to be mediated by a direct action of the vitamin on tumor cells, as well as through the host immune system, as revealed by nucleic acid synthetic patterns and nature of changes in the lymphocyte/neutrophil ratio, thymus weight and PHA-induced blastogenesis of peripheral lymphocytes.
在一个小鼠模型中评估了维生素A缺乏和补充对肿瘤发生率、肿瘤生长及预期寿命的影响。尽管所研究肿瘤类型的反应性质有所不同，但总体而言，在维持维生素A缺乏饮食的组中，肿瘤接种发生率增加且进一步生长，同时存活率下降。补充维生素A可延长潜伏期并延迟肿瘤出现，降低发生率和生长速度，并提高预期寿命。如核酸合成模式以及淋巴细胞/中性粒细胞比率、胸腺重量和外周淋巴细胞PHA诱导的细胞增殖变化的性质所显示，这些作用似乎是由维生素对肿瘤细胞的直接作用以及通过宿主免疫系统介导的。
