Department of Ophthalmology, National Taiwan University Hospital, 7 Zhongshan S. Rd., Zhongzheng Dist., Taipei, 10002, Taiwan.
Department of Ophthalmology, National Taiwan University Biomedical Park Hospital, Hsinchu, Taiwan.
Graefes Arch Clin Exp Ophthalmol. 2021 Aug;259(8):2095-2102. doi: 10.1007/s00417-021-05092-5. Epub 2021 Feb 2.
To report the anatomical characteristics of wide-based foveal pit and its possible associations with macular diseases.
Wide-based foveal pit was defined as a foveal base width (FBW) larger than the mean value plus one standard deviation of the normal population. Eyes with a wide-based foveal pit were retrospectively collected as the study group, and age- and sex-matched subjects with a normal FBW were recruited as the control group. FBW, area of foveal avascular zone (FAZ), and retinal artery trajectory (RAT) were compared between the two groups. The characteristics of the fellow eyes in the study group were also described.
Fifty-two eyes from 52 patients were identified as having a wide-based foveal pit; 43 (82.7%) were female. Both their FBW (474.7 ± 84.6 μm) and area of FAZ (0.50 ± 0.11 mm) were significantly larger than in the control group (297.6 ± 42.3 μm and 0.29 ± 0.10 mm, respectively; p < 0.001 for both), and they also had a wider RAT than the control group (p < 0.001). During follow-up, three eyes had developed idiopathic epiretinal membrane. As for their fellow eyes, they either also had a wide-based foveal pit (11 eyes) or had various macular diseases including idiopathic epiretinal membrane (27 eyes), macular hole (5 eyes), and others (16 eyes).
Eyes with a wide-based foveal pit had a large FAZ and a wide RAT, and they might have a predisposition to idiopathic epiretinal membrane formation. Their fellow eyes also had a predisposition to epiretinal membrane and macular hole.
报道宽基性中心小凹的解剖学特征及其与黄斑疾病的可能关联。
宽基性中心小凹定义为中心小凹基底宽度（FBW）大于正常人群平均值加一个标准差。将具有宽基性中心小凹的眼作为研究组，招募年龄和性别匹配的 FBW 正常的受试者作为对照组。比较两组的 FBW、中心小凹无血管区（FAZ）面积和视网膜动脉轨迹（RAT）。还描述了研究组中对侧眼的特征。
52 例患者的 52 只眼被确定为具有宽基性中心小凹；其中 43 只（82.7%）为女性。与对照组相比，他们的 FBW（474.7±84.6μm）和 FAZ 面积（0.50±0.11mm）均显著增大（分别为 p<0.001 和 p<0.001），并且他们的 RAT 也比对照组宽（p<0.001）。在随访期间，3 只眼发生特发性视网膜内界膜。对于他们的对侧眼，要么也有宽基性中心小凹（11 只眼），要么有各种黄斑疾病，包括特发性视网膜内界膜（27 只眼）、黄斑裂孔（5 只眼）和其他疾病（16 只眼）。
具有宽基性中心小凹的眼有较大的 FAZ 和较宽的 RAT，可能有形成特发性视网膜内界膜的倾向。他们的对侧眼也有形成视网膜内界膜和黄斑裂孔的倾向。
