Department of Ophthalmology, National Taiwan University Hospital, Taipei, Taiwan.
Department of Ophthalmology, National Taiwan University Hospital, Hsinchu Branch, Hsinchu, Taiwan.
Invest Ophthalmol Vis Sci. 2022 Feb 1;63(2):10. doi: 10.1167/iovs.63.2.10.
To measure the anatomical characteristics of the macula in fellow eyes of patients with unilateral idiopathic epiretinal membrane (ERM) and to compare them with normal controls.
A total of 83 fellow eyes with unilateral idiopathic ERM were gathered as the study group, and their age- and sex-matched subjects with no vitreomacular diseases were recruited as the control group. Macular structure parameters including foveal base width (FBW), central foveolar thickness (CFT), central subfield thickness (CST), area of foveal avascular zone (FAZ), and retinal artery trajectory (RAT) were measured using optical coherence tomography (OCT) and OCT angiography and were compared between two groups.
For the study group, the FBW (463.8 ± 79.6 µm) and area of FAZ (0.39 ± 0.12 mm2) were significantly larger than those in the control group (334.3 ± 76.5 µm, 0.31 ± 0.13 mm2). Their CST was thinner and their RAT was wider than those of the control group (P < 0.05 for all). In the normal population, females had a wider FBW, a thinner CFT, and a wider RAT than males (P < 0.05 for all).
Fellow eyes of the unilateral ERM had a larger FBW, a larger FAZ, a thinner CST, and a wider RAT than the normal population. This implicates that some centrifugal tractional force may exist on their macula, which eventually may result in the formation of idiopathic ERM. Females had a wider FBW, a thinner CFT, and a wider RAT than males, which may explain the higher prevalence of idiopathic ERM in females.
测量单侧特发性视网膜内界膜（ERM）患者对侧眼的黄斑解剖特征，并与正常对照组进行比较。
共纳入 83 只单侧特发性 ERM 患者的对侧眼作为观察组，选择年龄和性别匹配、无玻璃黄斑病变的患者作为对照组。使用光学相干断层扫描（OCT）和 OCT 血管造影测量黄斑结构参数，包括黄斑中心凹最小直径（FBW）、中心凹下厚度（CFT）、中心凹小区域厚度（CST）、黄斑无血管区面积（FAZ）和视网膜动脉轨迹（RAT），并比较两组间差异。
观察组的 FBW（463.8 ± 79.6 µm）和 FAZ 面积（0.39 ± 0.12 mm2）明显大于对照组（334.3 ± 76.5 µm，0.31 ± 0.13 mm2）。观察组的 CST 较薄，RAT 较宽，与对照组相比差异均有统计学意义（均 P < 0.05）。在正常人群中，女性的 FBW 较宽，CFT 较薄，RAT 较宽，与男性相比差异均有统计学意义（均 P < 0.05）。
单侧 ERM 对侧眼的 FBW、FAZ 较大，CST 较薄，RAT 较宽，这提示其黄斑可能存在某种离心性牵引力，最终可能导致特发性 ERM 的形成。女性的 FBW 较宽，CFT 较薄，RAT 较宽，这可能解释了女性特发性 ERM 发病率较高的原因。
