Universidad Autónoma de Madrid, Madrid, Spain.
Medical Oncology Department, Hospital Universitario Puerta de Hierro, C/Manuel de Falla, Majadahonda, 28222, Madrid, Spain.
Clin Transl Oncol. 2021 Jul;23(7):1325-1333. doi: 10.1007/s12094-020-02521-5. Epub 2021 Feb 2.
Lung cancer is the leading cause of cancer death in Spain. The objective of our study was to evaluate the characteristics of patients diagnosed with stages I-III non-small-cell lung cancer, as well as the impact that epidemiological changes, diagnostic improvements and surgical therapeutic innovations have had on survival in the past 20 years.
Retrospective analysis of patients diagnosed with early and locally advanced non-small-cell lung cancer between years 2000 and 2017 in our institution.
A total of 859 patients were included. An increase in the percentage of women diagnosed over time was observed. Statistically significant differences were observed in the mean age at diagnosis, with a progressive increase in the different periods. The percentage of current or former smokers was similar in all periods. Adenocarcinoma was the most frequent histologic type with a progressive increase in its frequency. The percentage of patients diagnosed in early stages has been increasing over the years. In stages I-II, there was a significant increase in the median survival (29.7 months: 2000-2004, 68.73 months: 2010-2014) that could be seen in stage III as well (14.7 months: 2000-2004, 30.63 months: 2015-2017).
A variation of clinical characteristics of lung cancer in Spain has been observed in recent years, as well as an improvement in survival in early and locally advanced stages, due not only to the treatments, but also to a more accurate detection of these tumors. Little progress has been made in tobacco habit with high stable percentages over the years.
肺癌是导致西班牙癌症死亡的主要原因。我们的研究目的是评估 I 期至 III 期非小细胞肺癌患者的特征，以及过去 20 年中流行病学变化、诊断改进和手术治疗创新对生存的影响。
回顾性分析 2000 年至 2017 年期间在我院诊断为早期和局部晚期非小细胞肺癌的患者。
共纳入 859 例患者。随着时间的推移，诊断为女性的患者比例有所增加。在诊断时的平均年龄方面观察到了统计学上的显著差异，不同时期的平均年龄呈递增趋势。各时期的现吸烟者或前吸烟者比例相似。腺癌是最常见的组织学类型，其频率呈递增趋势。诊断为早期阶段的患者比例逐年增加。在 I 期和 II 期，中位生存期有显著提高（29.7 个月：2000-2004 年，68.73 个月：2010-2014 年），III 期也有显著提高（14.7 个月：2000-2004 年，30.63 个月：2015-2017 年）。
近年来，西班牙肺癌的临床特征发生了变化，早期和局部晚期的生存率也有所提高，这不仅得益于治疗方法的改进，还得益于这些肿瘤更准确的检测。多年来，吸烟习惯一直保持着较高的稳定比例，几乎没有取得进展。
