胶乳荩草通过上调 miR-33 和 miR-155 减轻高脂饮食诱导的小鼠高脂血症和炎症，但不增加体重。

Upregulation of miR-33 and miR-155 by gum acacia mitigates hyperlipidaemia and inflammation but not weight increase induced by Western diet ingestion in mice.

机构信息

Department of Pharmaceutics and Pharmaceutical Technology, College of Pharmacy, Mutah University, Al-Karak, Jordan.

Department of Biochemistry, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, Egypt.

出版信息

Arch Physiol Biochem. 2023 Dec;129(4):847-853. doi: 10.1080/13813455.2021.1876734. Epub 2021 Feb 2.

DOI:10.1080/13813455.2021.1876734

PMID:33529079

Abstract

OBJECTIVE

This study, for the first time, investigates the effect of gum acacia (GA) on the expression of miR-33 and miR-155 and its association with the obesity and inflammation induced by Western diet (WD) consumption in mice.

METHODS

Animals were divided into: normal diet (ND) group, WD group, GA group and GA + WD group.

RESULTS

The WD group exhibited higher total body, liver, visceral fat weights, blood total cholesterol, triglycerides and glucose levels compared to ND group. The liver tissues showed severe inflammation and degeneration with higher hepatic TNF-α level. Interestingly, GA + WD group showed a decrease in the biochemical parameters and hepatic TNF-α level but had no effect on the weight increase. It also showed a significant upregulation of miR-33 and miR-155 compared to WD group.

CONCLUSIONS

GA mitigated the hyperlipidaemia and inflammation but not weight increase induced by WD ingestion via upregulation of miR-33 and miR-155 while reducing TNF-α level.

摘要

目的

本研究首次探讨了阿拉伯胶（GA）对 miR-33 和 miR-155 表达的影响，及其与西方饮食（WD）诱导的肥胖和炎症的关系。

方法

动物分为：正常饮食（ND）组、WD 组、GA 组和 GA+WD 组。

结果

与 ND 组相比，WD 组的总体重、肝重、内脏脂肪重量、血总胆固醇、甘油三酯和血糖水平均升高。肝组织显示严重炎症和变性，肝 TNF-α 水平升高。有趣的是，GA+WD 组的生化参数和肝 TNF-α 水平降低，但体重增加没有影响。与 WD 组相比，GA+WD 组 miR-33 和 miR-155 的表达显著上调。