Al-Qusous Madleen Nabil, Al Madanat Wajdi Khalaf Jamil, Mohamed Hussein Rasha
Department of Clinical Pharmacy, Faculty of Pharmacy, Mutah University, Al-Karak 61710, Jordan.
MedLabs Medical Laboratory, Al-Karak, Jordan.
Rep Biochem Mol Biol. 2023 Oct;12(3):415-424. doi: 10.61186/rbmb.12.3.415.
Obesity is an abnormal fat accumulation that adversely affects human health. Studies reported several vitamin deficiencies in obese patients. The current study investigates the deficiencies of vitamins D, B6, and B12 among Jordanian adults with hyperlipidemia and demonstrates the association between serum vitamin levels and metabolic and lipid profile parameters.
Sixty male subjects were divided into 40 hyperlipidemic patients (age: 45.9 yr. ±10.2) and 20 controls (age: 41.2 yr. ±10.7). The blood levels of triglycerides, total cholesterol, high density lipoprotein (HDL)-cholesterol, hemoglobin A1c, and vitamins D, B6, and B12 were measured.
The hyperlipidemic patients showed significantly increased triglycerides, total cholesterol, non-HDL, cholesterol/HDL ratio, low-density lipoprotein (LDL)- cholesterol levels, and decreased HDL-cholesterol levels compared to the controls. No significant differences were found in the blood levels of vitamin D, vitamin B6, or vitamin B12 between groups. However, 50% of the hyperlipidemic patients and 54.5% of the controls exhibited vitamin D deficiency. Only the hyperlipidemic patients exhibited deficiencies of vitamins B6 and B12 in 5.4% and 3.3% of cases, respectively. In the controls, vitamin B12 level was inversely associated with total cholesterol, whereas in the hyperlipidemic patients, vitamin B6 level was inversely correlated with total cholesterol and non-HDL levels.
The hyperlipidemic patients exhibited vitamins D, B6, and B12 deficiencies. Additionally, vitamins B6 and B12 levels were inversely correlated with total cholesterol and non-HDL levels. Our findings highlight the importance of routine evaluation of vitamin levels in patients with hyperlipidemia.
肥胖是一种异常的脂肪堆积，会对人类健康产生不利影响。研究报告称肥胖患者存在多种维生素缺乏的情况。本研究调查了约旦高脂血症成年患者中维生素D、B6和B12的缺乏情况，并阐述了血清维生素水平与代谢及血脂谱参数之间的关联。
60名男性受试者被分为40名高脂血症患者（年龄：45.9岁±10.2）和20名对照组（年龄：41.2岁±10.7）。测量了甘油三酯、总胆固醇、高密度脂蛋白（HDL）胆固醇、糖化血红蛋白A1c以及维生素D、B6和B12的血液水平。
与对照组相比，高脂血症患者的甘油三酯、总胆固醇、非HDL、胆固醇/HDL比值、低密度脂蛋白（LDL）胆固醇水平显著升高，HDL胆固醇水平降低。两组之间维生素D、维生素B6或维生素B12的血液水平未发现显著差异。然而，50%的高脂血症患者和54.5%的对照组存在维生素D缺乏。只有高脂血症患者分别有5.4%和3.3%的病例存在维生素B6和B12缺乏。在对照组中，维生素B12水平与总胆固醇呈负相关，而在高脂血症患者中，维生素B6水平与总胆固醇和非HDL水平呈负相关。
高脂血症患者存在维生素D、B6和B12缺乏。此外，维生素B6和B12水平与总胆固醇和非HDL水平呈负相关。我们的研究结果凸显了对高脂血症患者进行维生素水平常规评估的重要性。
