Department of Dermatology, University of Pisa, Pisa, Italy.
Italian National Research Council Institute of Clinical Physiology, Pisa, Italy.
Skin Res Technol. 2021 Mar;27(2):277-282. doi: 10.1111/srt.12942. Epub 2021 Feb 2.
High-frequency ultrasound (HFUS) is a non-invasive method that detects superficial skin features. Ultra-high frequencies (50-100 MHz) can reveal epidermis and dermis structures.
In this study, we describe the psoriatic plaque using a new device equipped with a 70 MHz probe (VEVO MD, Fujifilm, VisualSonics) and we assess the lesion before and after ixekizumab.
We examined the superficial hyperechoic band, the subepidermal hypoechoic band (SLEB), and the vascularization of the plaque in ten patients affected by plaque psoriasis.
The average superficial hyperechoic band thickness was 0.2157 mm before treatment, 0.1611 mm after 15 days, and 0.1354 mm (P < .05) after 30 days. The SLEB thickness was 0.7535 mm at baseline, 0.3300 mm after 15 days (P < .05), and 0.2007 mm (P < .05) after 30 days. The average percentage vascularization was 50.21% at baseline, 13.15% after 15 days (P < .05), and 5.97% after 30 days. UHFUS assessment highlighted the rapid action of the drug in terms of the decrease in vascularization after 15 days. It revealed a statistically significant reduction in SLEB thickness after 15 days and a significant reduction in the hyperechoic superficial band after 30 days.
VEVO MD provides physicians with high-resolution details of the psoriatic plaque, thus enabling tailored-made treatments.
高频超声（HFUS）是一种非侵入性的方法，可检测皮肤表面特征。超高频率（50-100MHz）可以显示表皮和真皮结构。
本研究使用配备 70MHz 探头的新型设备（VEVO MD，富士胶片，VisualSonics）描述银屑病斑块，并评估依奇珠单抗治疗前后的病变情况。
我们检查了 10 名斑块状银屑病患者的斑块的浅层高回声带、表皮下低回声带（SLEB）和血管化情况。
治疗前平均浅层高回声带厚度为 0.2157mm，治疗后 15 天为 0.1611mm，治疗后 30 天为 0.1354mm（P<.05）。SLEB 厚度在基线时为 0.7535mm，治疗后 15 天为 0.3300mm（P<.05），治疗后 30 天为 0.2007mm（P<.05）。平均血管化百分比在基线时为 50.21%，治疗后 15 天为 13.15%（P<.05），治疗后 30 天为 5.97%。UHFUS 评估突出了药物在 15 天后在降低血管化方面的快速作用。它显示在 15 天后 SLEB 厚度有统计学意义的降低，在 30 天后高回声浅层带有显著降低。
VEVO MD 为医生提供银屑病斑块的高分辨率细节，从而实现个性化治疗。
