Division of Endocrinology and Metabolism, Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taiwan.
Division of Endocrinology and Metabolism, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan.
Adv Clin Exp Med. 2021 Jan;30(1):35-40. doi: 10.17219/acem/128229.
Type 2 diabetes (T2D) is known to be one of the most prevalent diseases, and its prevalence is significantly associated with age and metabolic syndrome (MetS). Few studies have been conducted on liver function, MetS and insulin secretion among young adults.
In the present study, we explored the relationship between the liver function enzyme - alanine aminotransferase (ALT) - and first-phase insulin secretion (FPIS) among young adults.
There were 22,971 men and 28,740 women, aged 18-27 years, assigned to subgroups according to the presence of MetS and quartiles of ALT values. Simple correlation was applied to evaluate their relationship. The difference between the slopes of these relationships and FPIS were statistically analyzed with Chris's calculator.
Most values for metabolic parameters, including ALT and FPIS, were determined to be relatively high in individuals with MetS. By contrast, individuals with MetS had lower high-density-lipoprotein cholesterol (HDL-C) counts and FPIS. Similar results were observed in the quartiles of ALT. Significant positive results were also found in the linear model. Depending on the ALT level, the slope change of FPIS still demonstrated a positive correlation between ALT and FPIS. This correlation was stronger for men than for women.
A positive correlation between ALT and FPIS exists among young adults. Moreover, this correlation was stronger for men than for women. Both the cause and the effect require further investigation.
2 型糖尿病（T2D）是最常见的疾病之一，其患病率与年龄和代谢综合征（MetS）显著相关。很少有研究关注年轻人的肝功能、MetS 和胰岛素分泌。
本研究探讨了年轻成年人中肝功能酶-丙氨酸氨基转移酶（ALT）与第一时相胰岛素分泌（FPIS）之间的关系。
共有 22971 名男性和 28740 名女性，年龄在 18-27 岁之间，根据是否存在 MetS 和 ALT 值的四分位数分为亚组。采用简单相关分析评估它们之间的关系。用 Chris 的计算器统计分析这些关系和 FPIS 之间斜率差异的统计学意义。
代谢参数的大多数值，包括 ALT 和 FPIS，在患有 MetS 的个体中相对较高。相比之下，患有 MetS 的个体的高密度脂蛋白胆固醇（HDL-C）计数和 FPIS 较低。在 ALT 的四分位数中也观察到了类似的结果。线性模型也显示出显著的正结果。根据 ALT 水平，FPIS 的斜率变化仍然显示 ALT 和 FPIS 之间存在正相关。这种相关性在男性中比女性更强。
在年轻成年人中，ALT 和 FPIS 之间存在正相关。此外，这种相关性在男性中比女性更强。其因果关系需要进一步研究。
