杏仁核内多巴胺激动剂和拮抗剂对大鼠胃应激性损伤的影响。

Effects of intra-amygdalar dopamine agonists and antagonists on gastric stress lesions in rats.

作者信息

Ray A, Henke P G, Sullivan R M

机构信息

Department of Psychology, St. Francis Xavier University, Antigonish, N.S., Canada.

出版信息

Neurosci Lett. 1988 Feb 3;84(3):302-6. doi: 10.1016/0304-3940(88)90525-3.

DOI:10.1016/0304-3940(88)90525-3

PMID:3352956

Abstract

Microinjections of dopamine (DA, 3 and 30 micrograms) or its agonist apomorphine (3 micrograms) into the central amygdala (CEA) attenuated cold restraint (3 h at 4 degrees C)-induced gastric ulcer formation in rats. Pretreatment with DA antagonists, haloperidol and metoclopramide (both i.p. and intra-amygdalar) reversed the stress ulcer attenuating effect of DA. It is suggested that the CEA is one of the central sites for this DA cytoprotection and that D2 receptors are possibly involved in this effect.

摘要

向大鼠中央杏仁核（CEA）微量注射多巴胺（DA，3微克和30微克）或其激动剂阿扑吗啡（3微克）可减轻冷束缚（4℃，3小时）诱导的胃溃疡形成。用DA拮抗剂氟哌啶醇和胃复安（腹腔注射和杏仁核内注射）预处理可逆转DA对应激性溃疡的减轻作用。提示CEA是DA这种细胞保护作用的中枢部位之一，且D2受体可能参与此效应。