Mishra Abhinava K, Sharma Vartika, Mutsuddi Mousumi, Mukherjee Ashim
Department of Molecular and Human Genetics, Institute of Science, Banaras Hindu University, Varanasi 221 005, India; Molecular, Cellular, and Developmental Biology Department, University of California Santa Barbara, Santa Barbara, CA 93106, USA.
Department of Molecular and Human Genetics, Institute of Science, Banaras Hindu University, Varanasi 221 005, India.
Cell Signal. 2021 Jun;82:109937. doi: 10.1016/j.cellsig.2021.109937. Epub 2021 Jan 30.
Multicellular organisms depend on a handful of core signaling pathways that regulate a variety of cell fate choices. Often these relatively simple signals integrate to form a large and complex signaling network to achieve a distinct developmental fate in a context-specific manner. Various pathway-dependent and independent events control the assembly of signaling complexes. Notch pathway is one such conserved signaling mechanism that integrates with other signaling pathways to exhibit a context-dependent pleiotropic output. To understand how Notch signaling provides a spectrum of distinct outputs, it is important to understand various regulatory switches involved in mediating signaling cross-talk of Notch with other pathways. Here, we review our current understanding as to how Notch signal integrates with JNK and NF-κB signaling pathways in Drosophila to regulate various developmental events such as sensory organ precursor formation, innate immunity, dorsal closure, establishment of planar cell polarity as well as during proliferation and tumor progression. We highlight the importance of conserved signaling molecules during these cross-talks and debate further possibilities of novel switches that may be involved in mediating these cross-talk events.
多细胞生物依赖于少数几个核心信号通路，这些通路调节着多种细胞命运选择。通常，这些相对简单的信号整合形成一个庞大而复杂的信号网络，以在特定环境中实现独特的发育命运。各种依赖通路和不依赖通路的事件控制着信号复合物的组装。Notch通路就是这样一种保守的信号机制，它与其他信号通路整合，以呈现出依赖环境的多效性输出。为了理解Notch信号如何提供一系列不同的输出，了解介导Notch与其他通路信号相互作用的各种调节开关很重要。在这里，我们回顾了目前对于Notch信号如何在果蝇中与JNK和NF-κB信号通路整合，以调节各种发育事件（如感觉器官前体形成、先天免疫、背侧闭合、平面细胞极性建立以及增殖和肿瘤进展过程）的理解。我们强调了这些相互作用过程中保守信号分子的重要性，并讨论了可能参与介导这些相互作用事件的新型开关的进一步可能性。
