Osipo Clodia, Golde Todd E, Osborne Barbara A, Miele Lucio A
Breast Cancer Program, Cardinal Bernadin Cancer Center, Loyola University Medical Center, Maywood, IL 60513, USA.
Lab Invest. 2008 Jan;88(1):11-7. doi: 10.1038/labinvest.3700700. Epub 2007 Dec 3.
The canonical Notch pathway that has been well characterized over the past 25 years is relatively simple compared to the plethora of recently published data suggesting non-canonical signaling mechanisms and cross talk with other pathways. The manner in which other pathways cross talk with Notch signaling appears to be extraordinarily complex and, not surprisingly, context-dependent. While the physiological relevance of many of these interactions remains to be established, there is little doubt that Notch signaling is integrated with numerous other pathways in ways that appear increasingly complex. Among the most intricate cross talks described for Notch is its interaction with the NF-kappaB pathway, another major cell fate regulatory network involved in development, immunity, and cancer. Numerous reports over the last 11 years have described multiple cross talk mechanisms between Notch and NF-kappaB in diverse experimental models. This article will provide a brief overview of the published evidence for Notch-NF-kappaB cross talk, focusing on vertebrate systems.
在过去25年里已得到充分阐明的经典Notch信号通路，与最近大量发表的数据相比相对简单，这些数据表明存在非经典信号传导机制以及与其他通路的相互作用。其他通路与Notch信号相互作用的方式似乎极其复杂，而且不出所料，是依赖于背景的。虽然其中许多相互作用的生理相关性仍有待确定，但毫无疑问，Notch信号以日益复杂的方式与众多其他通路整合在一起。在描述的与Notch最复杂的相互作用中，有它与NF-κB通路的相互作用，NF-κB通路是另一个参与发育、免疫和癌症的主要细胞命运调控网络。在过去11年里，众多报告描述了在不同实验模型中Notch与NF-κB之间的多种相互作用机制。本文将简要概述已发表的关于Notch-NF-κB相互作用的证据，重点关注脊椎动物系统。
